Creutzfeldt-Jakob disease in Ireland: epidemiological aspects 1980-2002.
Authors
Horan, GailKeohane, Catherine
Molloy, Sophie
Howley, Rachel
Harney, Michael
Heffernan, Josephine
McGuigan, Christopher
Hutchinson, Michael
Brett, Francesca
Farrell, Michael
Affiliation
Department of Neuropathology, Cork University Hospital, Cork, Ireland.Issue Date
2012-02-03T15:08:38ZMeSH
AdultAge Distribution
Aged
Creutzfeldt-Jakob Syndrome/*epidemiology
*Epidemiologic Studies
Female
Humans
Ireland/epidemiology
Male
Middle Aged
Population Surveillance
Prospective Studies
Retrospective Studies
Risk Factors
Sex Distribution
Metadata
Show full item recordCitation
Eur Neurol. 2004;51(3):132-7. Epub 2004 Feb 26.Journal
European neurologyDOI
10.1159/000077063PubMed ID
14988606Abstract
Surveillance for Creutzfeldt-Jakob disease (CJD) has been carried out in the Republic of Ireland since 1980. Initial surveillance was passive and based on consented autopsy confirmation of CJD in patients in whom there was a high index of clinical suspicion. Since 1999, an active surveillance programme involving formal notification of all suspect CJD cases has been in place. The annual mortality rate has increased from 0.34 cases/million in 1980 to 1.27 cases/million in 2001. In all, 29 cases have been pathologically confirmed: 1 had variant CJD (vCJD), 1 had iatrogenic human growth hormone-induced CJD and 1 had fatal insomnia. Sporadic CJD (sCJD) accounted for the remainder. This paper details the change in incidence over 22 years as the surveillance programme in Ireland got under way; the increased incidence is attributed to better case ascertainment, as has occurred in other countries where active surveillance programmes have been established.Language
engISSN
0014-3022 (Print)0014-3022 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1159/000077063