Postoperative changes in the full-field electroretinogram following sevoflurane anaesthesia.
AffiliationCork University Hospital and University College Cork, Department of Anaesthesia, and Intensive Care Medicine, Cork, Ireland. firstname.lastname@example.org
Anesthesia Recovery Period
Anesthetics, Inhalation/*administration & dosage
Evoked Potentials/drug effects
Methyl Ethers/*administration & dosage
Nitrous Oxide/administration & dosage
Reaction Time/drug effects
Recovery of Function
Visual Pathways/drug effects
MetadataShow full item record
CitationEur J Anaesthesiol. 2004 Apr;21(4):272-8.
JournalEuropean journal of anaesthesiology
AbstractBACKGROUND AND OBJECTIVE: We tested the hypothesis that disturbances of the visual pathway persist following general anaesthesia, even after normal clinical discharge criteria have been met. METHODS: We performed full-field flash electroretinography in the right eye of 10 unpremedicated ASA I patients who underwent N2O/sevoflurane anaesthesia. Electroretinograms were recorded preoperatively, immediately after discharge from the recovery room and 2 h after discontinuation of sevoflurane. The time at which postanaesthesia discharge score first exceeded 9 was also noted. Data were analysed using paired, one-tailed Student's t-test. RESULTS: Latency of the b-wave on the photopic electroretinogram was greater at each postoperative time point (30.5 +/- 0.9 and 30 +/- 1.3 ms), compared to preoperative values (29.2 +/- 0.8 ms, P < 0.001 and P = 0.04, respectively). The A-B amplitude of the b-wave was less postoperatively (220.3 +/- 52.7 and 210.3 +/- 42.7 pV) compared to values before operation (248.1 +/- 57.6 microV, P = 0.03 and P = 0.01, respectively). Oscillatory potential latencies were greater at each postoperative time point (21.4 +/- 0.5 and 20.8 +/- 0.6 ms) compared to before operation (20.4 +/- 0.4 ms, P < 0.001 and P = 0.03, respectively). Oscillatory potential amplitudes were less at the first postoperative time point (17.5 +/- 6.1 microV), compared to preoperative values (22 +/- 6.4 microV, P = 0.04). CONCLUSIONS: Postoperative electroretinogram abnormalities are consistently present in patients who have undergone N2O/sevoflurane anaesthesia. These abnormalities persist beyond the time at which standard clinical discharge criteria have been met.
- Abnormalities of contrast sensitivity and electroretinogram following sevoflurane anaesthesia.
- Authors: Iohom G, Gardiner C, Whyte A, O'Connor G, Shorten G
- Issue date: 2004 Aug
- Postoperative changes in visual evoked potentials and cognitive function tests following sevoflurane anaesthesia.
- Authors: Iohom G, Collins I, Murphy D, Awad I, O'Connor G, McCarthy N, Shorten G
- Issue date: 2001 Dec
- Sevoflurane--nitrous oxide anaesthesia supplemented with remifentanil: effect on recovery and cognitive function.
- Authors: Breslin DS, Reid JE, Mirakhur RK, Hayes AH, McBrien ME
- Issue date: 2001 Feb
- Effects of halothane and sevoflurane on the electroretinogram of dogs.
- Authors: Yanase J, Ogawa H
- Issue date: 1997 Aug
- Effects of hypercapnia on the electroretinogram in sevoflurane and isoflurane anaesthetized dogs.
- Authors: Varela Lopez O, Alvarez Vazquez JC, Gonzalez Cantalapiedra A, Rosolen SG
- Issue date: 2010 Aug