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    Persistence of hepatitis C virus in a white population: associations with human leukocyte antigen class 1.

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    Authors
    Fanning, Liam J
    Kenny-Walsh, Elizabeth
    Shanahan, Fergus
    Affiliation
    Hepatitis C Unit, Department of Medicine, Clinical Sciences Building, Cork, University Hospital, National University of Ireland, Cork, Ireland., 1.fanning@ucc.ie
    Issue Date
    2012-02-03T15:08:15Z
    MeSH
    DNA/genetics/isolation & purification
    Data Interpretation, Statistical
    European Continental Ancestry Group/*genetics
    Female
    Gene Frequency/genetics
    Genotype
    HLA-A Antigens/genetics
    HLA-B Antigens/genetics
    HLA-C Antigens/genetics
    Haplotypes/genetics
    Hepacivirus/genetics/immunology
    Hepatitis C, Chronic/blood/*genetics/immunology
    Heterozygote
    Histocompatibility Antigens Class I/*genetics
    Homozygote
    Humans
    Ireland
    Male
    Polymerase Chain Reaction
    Polymorphism, Genetic/*genetics
    Viral Load
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    Citation
    Hum Immunol. 2004 Jul;65(7):745-51.
    Journal
    Human immunology
    URI
    http://hdl.handle.net/10147/208949
    DOI
    10.1016/j.humimm.2004.05.001
    PubMed ID
    15301865
    Abstract
    The aim of this study was to define novel associations between human leukocyte antigen (HLA) class 1 alleles and persistence or clearance of the hepatitis C virus (HCV) in a white population. All individuals in the study were seropositive for anti-HCV antibodies. Viral status was determined by the Roche HCV Amplicor test. HLA-A, -B, -C allelic group profile was molecularly defined by reverse line probe hybridization. The strongest individual allelic group associations with persistent HCV infection were HLA A*11 (p = 0.044) and Cw*04 (p = 0.006). However, only the HLA C*04 association survived correction for multiple comparisons. Further analysis of alleles in linkage with HLA Cw*04 revealed that the haplotype HLA A*11, Cw*04 was present in 11 individuals, 10 of whom were viremic (p = 0.05). No gene dosage effect was observed. No association between HLA class 1 allelic groups and aviremia and virus load was evident in this white population. HLA B*44 is associated with low virus load in human immunodeficiency virus disease, but this association was not evident in this HCV-infected population. Novel HLA class 1 alleles associated with persistence of HCV have been identified.
    Language
    eng
    ISSN
    0198-8859 (Print)
    0198-8859 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.humimm.2004.05.001
    Scopus Count
    Collections
    Cork University Hospital

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