Subclinical anaemia of chronic disease in adult patients with cystic fibrosis.
AffiliationRegional Adult Cystic Fibrosis Unit, Department of Respiratory Medicine, Cork, University Hospital, Wilton, Cork, Ireland. email@example.com
MetadataShow full item record
CitationJ Cyst Fibros. 2002 Mar;1(1):31-4.
JournalJournal of cystic fibrosis : official journal of the European Cystic Fibrosis, Society
AbstractPatients with chronic hypoxaemia develop secondary polycythaemia that improves oxygen-carrying capacity. Therefore, normal haemoglobin and haematocrit values in the presence of chronic arterial hypoxaemia in cystic fibrosis constitute 'relative anaemia'. We sought to determine the cause of this relative anaemia in patients with cystic fibrosis. We studied haematological indices and oxygen saturation in healthy volunteers (n=17) and in adult patients with cystic fibrosis (n=15). Patients with cystic fibrosis had lower resting arterial oxygen saturation when compared with normal volunteers (P<0.0001), and exercise led to a greater reduction in arterial oxygen saturation (P<0.0001). However, haemoglobin and haematocrit values in patients with cystic fibrosis did not significantly differ from normal volunteers. Serum iron (P=0.002), transferrin (P=0.02), and total iron-binding capacity (P=0.01) were lower in patients with cystic fibrosis. There were no significant differences in serum ferritin, percentage iron saturation, serum erythropoietin or red cell volume between the groups. The data presented demonstrate a characteristic picture of anaemia of chronic disease in adult patients with cystic fibrosis, except for normal haemoglobin and haematocrit values. Normal haemoglobin and haematocrit values in patients with cystic fibrosis appear to represent a combination of the effects of arterial hypoxaemia promoting polycythaemia, counterbalanced by chronic inflammation promoting anaemia of chronic disease.
- Lung disease severity, chronic inflammation, iron deficiency, and erythropoietin response in adults with cystic fibrosis.
- Authors: Fischer R, Simmerlein R, Huber RM, Schiffl H, Lang SM
- Issue date: 2007 Dec
- Arterial oxygen content is precisely maintained by graded erythrocytotic responses in settings of high/normal serum iron levels, and predicts exercise capacity: an observational study of hypoxaemic patients with pulmonary arteriovenous malformations.
- Authors: Santhirapala V, Williams LC, Tighe HC, Jackson JE, Shovlin CL
- Issue date: 2014
- Relative anemia and iron deficiency in cystic fibrosis.
- Authors: Ater JL, Herbst JJ, Landaw SA, O'Brien RT
- Issue date: 1983 May
- Functional iron deficiency in adults with cystic fibrosis.
- Authors: Pond MN, Morton AM, Conway SP
- Issue date: 1996 Aug
- Ferrokinetic and hematologic studies in cystic fibrosis patients.
- Authors: Wagener JS, McNeill GC, Taussig LM, Corrigan JJ, Lemen R
- Issue date: 1983 Summer