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    Subclinical anaemia of chronic disease in adult patients with cystic fibrosis.

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    Authors
    O'connor, T M
    McGrath, D S
    Short, C
    O'donnell, M J
    Sheehy, M
    Bredin, C P
    Affiliation
    Regional Adult Cystic Fibrosis Unit, Department of Respiratory Medicine, Cork, University Hospital, Wilton, Cork, Ireland. terryoconnor@eircom.net
    Issue Date
    2012-02-03T15:08:07Z
    MeSH
    Adult
    Anemia/blood/*etiology
    Anemia, Iron-Deficiency/etiology
    Anoxia/etiology
    Chronic Disease
    Cystic Fibrosis/blood/*complications
    Hematologic Tests
    Humans
    Oxygen/*blood
    Polycythemia/etiology
    
    Metadata
    Show full item record
    Citation
    J Cyst Fibros. 2002 Mar;1(1):31-4.
    Journal
    Journal of cystic fibrosis : official journal of the European Cystic Fibrosis, Society
    URI
    http://hdl.handle.net/10147/208945
    PubMed ID
    15463807
    Abstract
    Patients with chronic hypoxaemia develop secondary polycythaemia that improves oxygen-carrying capacity. Therefore, normal haemoglobin and haematocrit values in the presence of chronic arterial hypoxaemia in cystic fibrosis constitute 'relative anaemia'. We sought to determine the cause of this relative anaemia in patients with cystic fibrosis. We studied haematological indices and oxygen saturation in healthy volunteers (n=17) and in adult patients with cystic fibrosis (n=15). Patients with cystic fibrosis had lower resting arterial oxygen saturation when compared with normal volunteers (P<0.0001), and exercise led to a greater reduction in arterial oxygen saturation (P<0.0001). However, haemoglobin and haematocrit values in patients with cystic fibrosis did not significantly differ from normal volunteers. Serum iron (P=0.002), transferrin (P=0.02), and total iron-binding capacity (P=0.01) were lower in patients with cystic fibrosis. There were no significant differences in serum ferritin, percentage iron saturation, serum erythropoietin or red cell volume between the groups. The data presented demonstrate a characteristic picture of anaemia of chronic disease in adult patients with cystic fibrosis, except for normal haemoglobin and haematocrit values. Normal haemoglobin and haematocrit values in patients with cystic fibrosis appear to represent a combination of the effects of arterial hypoxaemia promoting polycythaemia, counterbalanced by chronic inflammation promoting anaemia of chronic disease.
    Language
    eng
    ISSN
    1569-1993 (Print)
    1569-1993 (Linking)
    Collections
    Cork University Hospital

    entitlement

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