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    [Significance of Toll-like receptors in the pathophysiology of surgical sepsis].

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    Authors
    Romics, Laszlo Jr
    Coffey, John Calvin
    Wang, Jiang Huai
    Redmond, Henry Paul
    Szabo, Gyongyi
    Affiliation
    Department of Surgery, Cork University Hospital, National University of Ireland, , Cork, Ireland. Laszlo.Romics@umassmed.edu
    Issue Date
    2012-02-03T15:07:56Z
    MeSH
    Humans
    Membrane Glycoproteins/*metabolism
    Receptors, Cell Surface/*metabolism
    Sepsis/etiology/*metabolism
    *Signal Transduction
    Surgical Wound Infection/*metabolism
    Toll-Like Receptors
    
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    Citation
    Magy Seb. 2004 Aug;57(4):229-35.
    Journal
    Magyar sebeszet
    URI
    http://hdl.handle.net/10147/208938
    PubMed ID
    15570917
    Abstract
    The discovery of Toll-like receptors has substantially changed our knowledge of pathogen recognition. 11 Toll-like receptors have so far been described in humans. These recognize distinct pathogen associated molecular patterns, as well as endogenous ligands and small molecular synthetic compounds. TLRs have a multifunctional role in pathogen-triggered immune responses and represent an important connection between the "innate" and "adaptive" immunity. The role of the TLRs in the recognition of pathogens renders them a key figure in the activation of the immune response during surgical sepsis. However, emerging evidence points to a fundamental role in tumorigenesis, transplantation, wound healing, atherogenesis and inflammatory bowel disease. The aim hence was to review experimental data pertaining to the activation of TLR signalling pathways in conditions associated with surgical sepsis. A systematic review of the literature was undertaken by searching the MEDLINE database for the period 1966-2004 without language restriction. The paper also analyses the possible therapeutic utilization of the TLR signalling pathways in surgical sepsis.
    Language
    hun
    ISSN
    0025-0295 (Print)
    0025-0295 (Linking)
    Collections
    Cork University Hospital

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