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    Activated endothelial interleukin-1beta, -6, and -8 concentrations and intercellular adhesion molecule-1 expression are attenuated by lidocaine.

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    Authors
    Lan, Wei
    Harmon, Dominic C
    Wang, Jiang H
    Shorten, George D
    Redmond, Paul H
    Affiliation
    Academic Department of Surgery, Cork University Hospital, University College,, Cork, Ireland. dweilan@hotmail.com
    Issue Date
    2012-02-03T15:07:44Z
    MeSH
    Anesthetics, Local/*pharmacology
    Endothelial Cells/drug effects/metabolism
    Enzyme-Linked Immunosorbent Assay
    Humans
    Intercellular Adhesion Molecule-1/*biosynthesis
    Interleukin-1/*metabolism
    Interleukin-6/*metabolism
    Interleukin-8/*metabolism
    Lidocaine/*pharmacology
    Tumor Necrosis Factor-alpha/biosynthesis
    
    Metadata
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    Citation
    Anesth Analg. 2005 Feb;100(2):409-12.
    Journal
    Anesthesia and analgesia
    URI
    http://hdl.handle.net/10147/208931
    DOI
    10.1213/01.ANE.0000142113.39092.87
    PubMed ID
    15673867
    Abstract
    Endothelial cells play a key role in ischemia reperfusion injury. We investigated the effects of lidocaine on activated human umbilical vein endothelial cell (HUVEC) interleukin (IL)-1beta, IL-6, and IL-8 concentrations and intercellular adhesion molecule-1 (ICAM-1) expression. HUVECs were pretreated with different concentrations of lidocaine (0 to 0.5 mg/mL) for 60 min, thereafter tumor necrosis factor-alpha was added at a concentration of 2.5 ng/mL and the cells incubated for 4 h. Supernatants were harvested, and cytokine concentrations were analyzed by enzyme-linked immunosorbent assay. Endothelial ICAM-1 expression was analyzed by using flow cytometry. Differences were assessed using analysis of variance and post hoc unpaired Student's t-test where appropriate. Lidocaine (0.5 mg/mL) decreased IL-1beta (1.89 +/- 0.11 versus 4.16 +/- 1.27 pg/mL; P = 0.009), IL-6 (65.5 +/- 5.14 versus 162 +/- 11.5 pg/mL; P < 0.001), and IL-8 (3869 +/- 785 versus 14,961 +/- 406 pg/mL; P < 0.001) concentrations compared with the control. IL-1beta, IL-6, and IL-8 concentrations in HUVECs treated with clinically relevant plasma concentrations of lidocaine (0.005 mg/mL) were similar to control. ICAM-1 expression on lidocaine-treated (0.05 mg/mL) HUVECs was less than on controls (198 +/- 52.7 versus 298 +/- 50.3; Mean Channel Fluorescence; P < 0.001). Activated endothelial IL-1beta, IL-6, and IL-8 concentrations and ICAM-1 expression are attenuated only by lidocaine at concentrations larger than clinically relevant concentrations.
    Language
    eng
    ISSN
    0003-2999 (Print)
    0003-2999 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1213/01.ANE.0000142113.39092.87
    Scopus Count
    Collections
    Cork University Hospital

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