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    Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease.

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    Authors
    Shanahan, Fergus
    Affiliation
    Alimentary Pharmabiotic Centre, Department of Medicine, Clinical Science Bldg.,, Cork University Hospital, Cork, Ireland. F.Shanahan@ucc.ie
    Issue Date
    2012-02-03T15:07:37Z
    MeSH
    Animals
    Humans
    Inflammatory Bowel Diseases/*drug
    therapy/immunology/microbiology/*physiopathology
    *Probiotics
    Signal Transduction
    
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    Citation
    Am J Physiol Gastrointest Liver Physiol. 2005 Mar;288(3):G417-21.
    Journal
    American journal of physiology. Gastrointestinal and liver physiology
    URI
    http://hdl.handle.net/10147/208926
    DOI
    10.1152/ajpgi.00421.2004
    PubMed ID
    15701620
    Abstract
    Mechanisms underlying the conditioning influence of the intestinal flora on mucosal homeostasis, including development and function of immune responses, are attracting increasing scientific scrutiny. The intestinal flora is a positive asset to host defense, but some of its components may, in genetically susceptible hosts, become a risk factor for development of inflammatory bowel disease (IBD). It follows that strategies to enhance assets or offset microbial liabilities represent a therapeutic option; therein lies the rationale for manipulation of the flora in IBD. In addition, the diversity of regulatory signalling among the flora and host epithelum, lymphoid tissue, and neuromuscular apparatus is an untapped reservoir from which novel therapeutics may be mined. Moreover, the capacity to engineer food-grade or commensal bacteria to deliver therapeutic molecules to the intestinal mucosa promises to extend the scope of microbial manipulation for the benefit of mankind.
    Language
    eng
    ISSN
    0193-1857 (Print)
    0193-1857 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1152/ajpgi.00421.2004
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

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