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    Duration of increased bleeding tendency after cessation of aspirin therapy.

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    Authors
    Cahill, Ronan A
    McGreal, Gerard T
    Crowe, Basil H
    Ryan, Damien A
    Manning, Brian J
    Cahill, Mary R
    Redmond, H Paul
    Affiliation
    Department of Surgery, NUI (Cork), Cork University Hospital, Cork, Ireland.
    Issue Date
    2012-02-03T15:07:18Z
    MeSH
    Adult
    Aspirin/*administration & dosage
    *Bleeding Time
    Double-Blind Method
    Female
    Hemostasis/*drug effects
    Humans
    Male
    Platelet Aggregation Inhibitors/*administration & dosage
    Platelet Function Tests
    Prospective Studies
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    Citation
    J Am Coll Surg. 2005 Apr;200(4):564-73; quiz A59-61.
    Journal
    Journal of the American College of Surgeons
    URI
    http://hdl.handle.net/10147/208915
    DOI
    10.1016/j.jamcollsurg.2004.11.002
    PubMed ID
    15804471
    Abstract
    BACKGROUND: Aspirin has a significant effect on hemostasis, so it is often recommended that patients taking aspirin discontinue treatment before elective surgery. While off aspirin, these patients may be at risk of thrombosis. The optimum period of time that aspirin should be withheld is controversial. The aim of this study was to establish the duration of the antihemostatic effect of prolonged aspirin therapy. STUDY DESIGN: In a prospective study, 51 healthy volunteers were randomly assigned into 3 groups, each receiving an identical tablet for 14 days. One group received a placebo tablet; individuals in the other two groups received either 75 mg or 300 mg of aspirin once a day. Template bleeding times and specific platelet function testing (using the PFA-100; Dade Behring) were carried out on subjects before therapy and again after its completion until they returned to baseline. RESULTS: Thirty-eight volunteers complied sufficiently with the protocol to provide useful results. All bleeding times normalized within 96 hours and all platelet function tests within 144 hours after stopping aspirin. There was no demonstrable hemostatic defect in any volunteer persisting by or beyond the sixth day after treatment cessation. There was no apparent difference in duration of effect between those taking either 75 mg or 300 mg of aspirin. CONCLUSIONS: This study uses sensitive measures of platelet function to demonstrate the duration of increased bleeding tendency after withdrawal of aspirin therapy. It supports discontinuation of aspirin therapy 5 days before elective surgery (with the operation being performed on the sixth day).
    Language
    eng
    ISSN
    1072-7515 (Print)
    1072-7515 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jamcollsurg.2004.11.002
    Scopus Count
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    Cork University Hospital

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