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dc.contributor.authorQuigley, Eamonn M M
dc.date.accessioned2012-02-03T15:07:15Z
dc.date.available2012-02-03T15:07:15Z
dc.date.issued2012-02-03T15:07:15Z
dc.identifier.citationGastroenterol Clin North Am. 2005 Jun;34(2):221-33, vi.en_GB
dc.identifier.issn0889-8553 (Print)en_GB
dc.identifier.issn0889-8553 (Linking)en_GB
dc.identifier.pmid15862931en_GB
dc.identifier.doi10.1016/j.gtc.2005.02.010en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208913
dc.description.abstractMotility and visceral hypersentitivity are regarded as the primary mechanisms of symptom development in irritable bowel syndrome(IBS). While a variety of motor abnormalities have been described throughout the gastrointestinal tract in IBS, their specificity and relationship to symptoms remain unclear. Visceral hypersensitivity is ubiquitous in functional gastrointestinal disease and is especially common in IBS. Again, however, its specificity for IBS has been questioned. Many factors, including stress and psychopathology,complicate the interpretation of these phenomena and new re-search suggests that mucosal inflammation and luminal factors may be more fundamental to the etiology of this common disorder.
dc.language.isoengen_GB
dc.subject.meshBiological Markersen_GB
dc.subject.meshGastrointestinal Motility/*physiologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshHyperalgesia/physiopathologyen_GB
dc.subject.meshIrritable Bowel Syndrome/*physiopathologyen_GB
dc.titleDisturbances of motility and visceral hypersensitivity in irritable bowel syndrome: biological markers or epiphenomenon.en_GB
dc.contributor.departmentDepartment of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital,, Clinical Sciences Building, Cork, Ireland. e.quigley@ucc.ieen_GB
dc.identifier.journalGastroenterology clinics of North Americaen_GB
dc.description.provinceMunster
html.description.abstractMotility and visceral hypersentitivity are regarded as the primary mechanisms of symptom development in irritable bowel syndrome(IBS). While a variety of motor abnormalities have been described throughout the gastrointestinal tract in IBS, their specificity and relationship to symptoms remain unclear. Visceral hypersensitivity is ubiquitous in functional gastrointestinal disease and is especially common in IBS. Again, however, its specificity for IBS has been questioned. Many factors, including stress and psychopathology,complicate the interpretation of these phenomena and new re-search suggests that mucosal inflammation and luminal factors may be more fundamental to the etiology of this common disorder.


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