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    Disturbances of motility and visceral hypersensitivity in irritable bowel syndrome: biological markers or epiphenomenon.

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    Authors
    Quigley, Eamonn M M
    Affiliation
    Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital,, Clinical Sciences Building, Cork, Ireland. e.quigley@ucc.ie
    Issue Date
    2012-02-03T15:07:15Z
    MeSH
    Biological Markers
    Gastrointestinal Motility/*physiology
    Humans
    Hyperalgesia/physiopathology
    Irritable Bowel Syndrome/*physiopathology
    
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    Citation
    Gastroenterol Clin North Am. 2005 Jun;34(2):221-33, vi.
    Journal
    Gastroenterology clinics of North America
    URI
    http://hdl.handle.net/10147/208913
    DOI
    10.1016/j.gtc.2005.02.010
    PubMed ID
    15862931
    Abstract
    Motility and visceral hypersentitivity are regarded as the primary mechanisms of symptom development in irritable bowel syndrome(IBS). While a variety of motor abnormalities have been described throughout the gastrointestinal tract in IBS, their specificity and relationship to symptoms remain unclear. Visceral hypersensitivity is ubiquitous in functional gastrointestinal disease and is especially common in IBS. Again, however, its specificity for IBS has been questioned. Many factors, including stress and psychopathology,complicate the interpretation of these phenomena and new re-search suggests that mucosal inflammation and luminal factors may be more fundamental to the etiology of this common disorder.
    Language
    eng
    ISSN
    0889-8553 (Print)
    0889-8553 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.gtc.2005.02.010
    Scopus Count
    Collections
    Cork University Hospital

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