Disturbances of motility and visceral hypersensitivity in irritable bowel syndrome: biological markers or epiphenomenon.
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Authors
Quigley, Eamonn M MAffiliation
Department of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital,, Clinical Sciences Building, Cork, Ireland. e.quigley@ucc.ieIssue Date
2012-02-03T15:07:15ZMeSH
Biological MarkersGastrointestinal Motility/*physiology
Humans
Hyperalgesia/physiopathology
Irritable Bowel Syndrome/*physiopathology
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Gastroenterol Clin North Am. 2005 Jun;34(2):221-33, vi.Journal
Gastroenterology clinics of North AmericaDOI
10.1016/j.gtc.2005.02.010PubMed ID
15862931Abstract
Motility and visceral hypersentitivity are regarded as the primary mechanisms of symptom development in irritable bowel syndrome(IBS). While a variety of motor abnormalities have been described throughout the gastrointestinal tract in IBS, their specificity and relationship to symptoms remain unclear. Visceral hypersensitivity is ubiquitous in functional gastrointestinal disease and is especially common in IBS. Again, however, its specificity for IBS has been questioned. Many factors, including stress and psychopathology,complicate the interpretation of these phenomena and new re-search suggests that mucosal inflammation and luminal factors may be more fundamental to the etiology of this common disorder.Language
engISSN
0889-8553 (Print)0889-8553 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1016/j.gtc.2005.02.010
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