Disturbances of motility and visceral hypersensitivity in irritable bowel syndrome: biological markers or epiphenomenon.
AuthorsQuigley, Eamonn M M
AffiliationDepartment of Medicine, Alimentary Pharmabiotic Centre, Cork University Hospital,, Clinical Sciences Building, Cork, Ireland. email@example.com
Irritable Bowel Syndrome/*physiopathology
MetadataShow full item record
CitationGastroenterol Clin North Am. 2005 Jun;34(2):221-33, vi.
JournalGastroenterology clinics of North America
AbstractMotility and visceral hypersentitivity are regarded as the primary mechanisms of symptom development in irritable bowel syndrome(IBS). While a variety of motor abnormalities have been described throughout the gastrointestinal tract in IBS, their specificity and relationship to symptoms remain unclear. Visceral hypersensitivity is ubiquitous in functional gastrointestinal disease and is especially common in IBS. Again, however, its specificity for IBS has been questioned. Many factors, including stress and psychopathology,complicate the interpretation of these phenomena and new re-search suggests that mucosal inflammation and luminal factors may be more fundamental to the etiology of this common disorder.