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    Advanced Merkel cell cancer and the elderly.

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    Authors
    Bird, B R
    Myers, D
    Ryan, S M
    Wyse, G
    O'Sullivan, S T
    Breathnach, O S
    Affiliation
    Department of Medical Oncology, Cork University Hospital, Wilton, Cork., brianbird@eircom.net
    Issue Date
    2012-02-03T15:07:13Z
    MeSH
    Aged
    Antineoplastic Agents/*therapeutic use
    Carboplatin/*therapeutic use
    Carcinoma, Merkel Cell/diagnosis/*drug therapy
    Disease Progression
    Etoposide/*therapeutic use
    Groin/pathology
    Humans
    Knee/pathology
    Male
    Neoplasm Staging
    Skin Neoplasms/diagnosis/*drug therapy
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    Metadata
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    Citation
    Ir J Med Sci. 2005 Jan-Mar;174(1):58-60.
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/208912
    PubMed ID
    15868892
    Abstract
    BACKGROUND: Merkel cell cancer (MCC) is an uncommon neuroendocrine skin cancer occurring predominantly in elderly Caucasians. It tends to metastasize to regional lymph nodes and viscera and is sensitive to chemotherapy but recurs rapidly. AIM: To report one such case, its response to chemotherapy and briefly review the literature. METHODS: A 73-year-old male with a fungating primary lesion on his left knee and ulcerated inguinal lymph nodes was diagnosed with MCC and treated with chemotherapy. The two largest case series and reviews of case reports were summarised. RESULTS: His ulcer healed after two cycles of carboplatin and etoposide with improvement in quality of life. Overall response rates of nearly 60% to chemotherapy are reported but median survival is only nine months with metastatic disease. CONCLUSIONS: Chemotherapy should be considered for fit elderly patients with MCC who have recurrent or advanced disease.
    Language
    eng
    ISSN
    0021-1265 (Print)
    0021-1265 (Linking)
    Collections
    Cork University Hospital

    entitlement

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