• Login
    View Item 
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Munster
    • Cork University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4943
    UlsterS
    4943
    Connacht
    1618
    Munster
    58
    Leinster
    454

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementORCID Unique identifiers for ResearchersHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Activated protein C attenuates acute ischaemia reperfusion injury in skeletal muscle.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Authors
    Dillon, J P
    Laing, A J
    Cahill, R A
    O'Brien, G C
    Street, J T
    Wang, J H
    Mc Guinness, A
    Redmond, H P
    Affiliation
    Department of Academic Surgery and Orthopaedics, Cork University Hospital and, National University of Ireland, Cork, Ireland. dillionjp@o2.ie
    Issue Date
    2012-02-03T15:06:55Z
    MeSH
    Acute Disease
    Animals
    Antigens, CD18/analysis
    Humans
    Male
    Muscle, Skeletal/*blood supply
    Neutrophil Infiltration/drug effects
    Neutrophils/drug effects/metabolism
    Protein C/*therapeutic use
    Rats
    Rats, Sprague-Dawley
    Reactive Oxygen Species/metabolism
    Reperfusion Injury/*prevention & control
    Tumor Necrosis Factor-alpha/pharmacology
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    J Orthop Res. 2005 Nov;23(6):1454-9. Epub 2005 Jul 1.
    Journal
    Journal of orthopaedic research : official publication of the Orthopaedic, Research Society
    URI
    http://hdl.handle.net/10147/208902
    DOI
    10.1016/j.orthres.2005.04.009.1100230631
    PubMed ID
    15994053
    Abstract
    Activated protein C (APC) is an endogenous anti-coagulant with anti-inflammatory properties. The purpose of the present study was to evaluate the effects of activated protein C in the setting of skeletal muscle ischaemia reperfusion injury (IRI). IRI was induced in rats by applying rubber bands above the levels of the greater trochanters bilaterally for a period of 2h followed by 12h reperfusion. Treatment groups received either equal volumes of normal saline or activated protein C prior to tourniquet release. Following 12h reperfusion, muscle function was assessed electrophysiologically by electrical field stimulation. The animals were then sacrificed and skeletal muscle harvested for evaluation. Activated protein C significantly attenuated skeletal muscle reperfusion injury as shown by reduced myeloperoxidase content, wet to dry ratio and electrical properties of skeletal muscle. Further in vitro work was carried out on neutrophils isolated from healthy volunteers to determine the direct effect of APC on neutrophil function. The effects of APC on TNF-alpha stimulated neutrophils were examined by measuring CD18 expression as well as reactive oxygen species generation. The in vitro work demonstrated a reduction in CD18 expression and reactive oxygen species generation. We conclude that activated protein C may have a protective role in the setting of skeletal muscle ischaemia reperfusion injury and that this is in part mediated by a direct inhibitory effect on neutrophil activation.
    Language
    eng
    ISSN
    0736-0266 (Print)
    0736-0266 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.orthres.2005.04.009.1100230631
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

    Related articles

    • Hypertonic saline reduces skeletal muscle injury and associated remote organ injury following ischemia reperfusion injury.
    • Authors: Dillon JP, Laing AJ, Chandler JR, Shields CJ, Wang JH, McGuinness A, Redmond HP
    • Issue date: 2008 Oct
    • Pravastatin attenuates tourniquet-induced skeletal muscle ischemia reperfusion injury.
    • Authors: Dillon JP, Laing AJ, Chandler JR, Wang JH, McGuinness A, Redmond HP
    • Issue date: 2006 Feb
    • Activated protein C prevents hepatic ischaemia-reperfusion injury in rats.
    • Authors: Kuriyama N, Isaji S, Hamada T, Kishiwada M, Ohsawa I, Usui M, Sakurai H, Tabata M, Suzuki K, Uemoto S
    • Issue date: 2009 Feb
    • Statins inhibit neutrophil infiltration in skeletal muscle reperfusion injury.
    • Authors: Cowled PA, Khanna A, Laws PE, Field JB, Varelias A, Fitridge RA
    • Issue date: 2007 Aug
    • Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury.
    • Authors: Crinnion JN, Homer-Vanniasinkam S, Hatton R, Parkin SM, Gough MJ
    • Issue date: 1994 Dec
    Health Library Ireland | Health Service Executive | Jervis House, Jervis Street | Republic of Ireland | Eircode: D01 W596
    lenus@hse.ie | Tel: +353-1-7786275
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.