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    Intravitreal triamcinolone for diffuse diabetic macular oedema.

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    Authors
    Gibran, S K
    Cullinane, A
    Jungkim, S
    Cleary, P E
    Affiliation
    Department of Ophthalmology, Cork University Hospital, Cork, Ireland., syedgibran@yahoo.com
    Issue Date
    2012-02-03T15:06:51Z
    MeSH
    Aged
    Anti-Inflammatory Agents/*therapeutic use
    Diabetic Retinopathy/*drug therapy/pathology/physiopathology
    Female
    Humans
    Macula Lutea/pathology
    Macular Edema/*drug therapy/pathology/physiopathology
    Male
    Middle Aged
    Prospective Studies
    Treatment Outcome
    Triamcinolone Acetonide/*therapeutic use
    Visual Acuity/drug effects
    Vitreous Body
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    Citation
    Eye (Lond). 2006 Jun;20(6):720-4. Epub 2005 Jul 8.
    Journal
    Eye (London, England)
    URI
    http://hdl.handle.net/10147/208899
    DOI
    10.1038/sj.eye.6701992
    PubMed ID
    16021193
    Abstract
    AIM: To evaluate the efficacy of intravitreal triamcinolone (IVTA) for the treatment of diffuse diabetic macular oedema (DME) refractory to conventional argon macular laser therapy. METHODS: A prospective, consecutive, and noncomparative case series was undertaken involving 38 eyes of 38 patients with refractory DME. Triamcinolone acetonide (4 mg) in 0.1 ml was injected intravitreally. LogMar visual acuity (VA) and macular thickness measured by ocular coherence tomography (OCT) were assessed preoperatively and postoperatively at 1, 3, and 6 months. RESULTS: All patients completed 6 months of follow up. VA (mean+/-SD) improved from 0.905+/-0.23 to 0.605+/-0.28, 0.555+/-0.29, and 0.730+/-0.30 at 1, 3, and 6 months, respectively. Macular thickness baseline (mean+/-SD) on OCT was 418.7+/-104.2 microm and this decreased to 276.9+/-72.6 microm, 250.6+/-53.1 microm, and 308.8+/-87.3 microm at 1, 3, and 6 months, respectively. CONCLUSIONS: IVTA may be a potential temporary treatment for refractory DME. It is effective in decreasing macular thickness and improving VA but the effect lasts approximately for 6 months in the majority of patients. Further investigations are required to establish the safety of IVTA for the treatment of DME.
    Language
    eng
    ISSN
    0950-222X (Print)
    0950-222X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.eye.6701992
    Scopus Count
    Collections
    Cork University Hospital

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