Anatomy of melancholia: focus on hypothalamic-pituitary-adrenal axis overactivity and the role of vasopressin.
AffiliationDepartment of Psychiatry and Alimentary Pharmabiotic Centre, Cork University, Hospital, Ireland. email@example.com
MetadataShow full item record
CitationJ Anat. 2005 Sep;207(3):259-64.
JournalJournal of anatomy
AbstractOveractivity of the hypothalamic-pituitary-adrenal (HPA) axis characterized by hypercortisolism, adrenal hyperplasia and abnormalities in negative feedback is the most consistently described biological abnormality in melancholic depression. Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) are the main secretagogues of the HPA/stress system. Produced in the parvicellular division of the hypothalamic paraventricular nucleus the release of these peptides is influenced by inputs from monoaminergic neurones. In depression, anterior pituitary CRH1 receptors are down-regulated and response to CRH infusion is blunted. By contrast, vasopressin V3 receptors on the anterior pituitary show enhanced response to AVP stimulation and this enhancement plays a key role in maintaining HPA overactivity.
- Vasopressin and the regulation of hypothalamic-pituitary-adrenal axis function: implications for the pathophysiology of depression.
- Authors: Scott LV, Dinan TG
- Issue date: 1998
- Regulation of the hypothalamic-pituitary-adrenal axis.
- Authors: Papadimitriou A, Priftis KN
- Issue date: 2009
- Role of the hypothalamic pituitary adrenal axis in the control of the response to stress and infection.
- Authors: McCann SM, Antunes-Rodrigues J, Franci CR, Anselmo-Franci JA, Karanth S, Rettori V
- Issue date: 2000 Oct
- The stress system in the human brain in depression and neurodegeneration.
- Authors: Swaab DF, Bao AM, Lucassen PJ
- Issue date: 2005 May
- Temazepam triggers the release of vasopressin into the rat hypothalamic paraventricular nucleus: novel insight into benzodiazepine action on hypothalamic-pituitary-adrenocortical system activity during stress.
- Authors: Welt T, Engelmann M, Renner U, Erhardt A, Müller MB, Landgraf R, Holsboer F, Keck ME
- Issue date: 2006 Dec