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    A characterization of anaerobic colonization and associated mucosal adaptations in the undiseased ileal pouch.

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    Authors
    Smith, F M
    Coffey, J C
    Kell, M R
    O'Sullivan, M
    Redmond, H P
    Kirwan, W O
    Affiliation
    Department of Surgery University College Cork and Cork University Hospital,, National University of Ireland.
    Issue Date
    2012-02-03T15:06:27Z
    MeSH
    Adenomatous Polyposis Coli/surgery
    Bacteroides/*isolation & purification
    Bifidobacterium/*isolation & purification
    Clostridium perfringens/*isolation & purification
    Colitis, Ulcerative/surgery
    Female
    Humans
    Intestinal Mucosa/*pathology
    Male
    Pouchitis/*microbiology/*pathology
    
    Metadata
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    Citation
    Colorectal Dis. 2005 Nov;7(6):563-70.
    Journal
    Colorectal disease : the official journal of the Association of Coloproctology of, Great Britain and Ireland
    URI
    http://hdl.handle.net/10147/208885
    DOI
    10.1111/j.1463-1318.2005.00833.x
    PubMed ID
    16232236
    Abstract
    INTRODUCTION: The resolution of pouchitis with metronidazole points to an anaerobic aetiology. Pouchitis is mainly seen in patients with ulcerative colitis pouches (UCP). We have recently found that sulphate reducing bacteria (SRB), a species of strict anaerobe, colonize UCP exclusively. Herein, we aimed to correlate levels of different bacterial species (including SRB) with mucosal inflammation and morphology. METHODS: Following ethical approval, fresh faecal samples and mucosal biopsies were taken from 9 patients with UCP and 5 patients with familial adenomatous polyposis pouches (FAPP). For the purposes of comparison, faecal samples and mucosal biopsies were also taken from the stomas of 7 of the 9 patients with UC (UCS). Colonization by four types of strict anaerobes (SRB, Clostridium perfringens, Bifidobacteria and Bacteroides) as well as by three types of facultative anaerobes (Enterococci, Coliforms and Lactobacilli) was evaluated. Inflammatory scores and mucosal morphology were assessed histologically in a blinded fashion by a pathologist. RESULTS: In general, strict anaerobes predominated over facultative in the UCP (P = 0.041). SRB were present in UCP exclusively. Even after exclusion of SRB from total bacterial counts, strict anaerobes still predominated. In the UCS, facultative anaerobes predominated. Strict and facultative anaerobes were present at similar levels in the FAPP. Enterococci were present at significantly reduced levels in the UCP when compared with the UCS (P = 0.031). When levels of SRB and other anaerobic species were individually correlated with mucosal inflammation and morphology, no trends were observed. CONCLUSION: We have previously identified that SRB exclusively colonize UCP. In addition we have now identified a novel increase in the strict/facultative anaerobic ratio within the UCP compared to UCS. These stark differences in bacterial colonization, however, appear to have limited impact on mucosal inflammation or morphology.
    Language
    eng
    ISSN
    1462-8910 (Print)
    1462-8910 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1463-1318.2005.00833.x
    Scopus Count
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    Cork University Hospital

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