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    The immunological consequences of injury.

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    Authors
    Ni Choileain, N
    Redmond, H P
    Affiliation
    Department of Surgery, Cork University Hospital, Ireland. nnc1@eircom.net
    Issue Date
    2012-02-03T15:05:53Z
    MeSH
    Antibody Formation/*physiology
    Female
    Humans
    Immunity, Innate/*physiology
    Immunocompromised Host/*immunology
    Injury Severity Score
    Male
    Multiple Trauma/diagnosis/immunology/mortality
    Prognosis
    Risk Assessment
    Survival Rate
    Systemic Inflammatory Response Syndrome/diagnosis/*immunology/mortality
    Wounds and Injuries/diagnosis/*immunology/mortality
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    Citation
    Surgeon. 2006 Feb;4(1):23-31.
    Journal
    The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
    URI
    http://hdl.handle.net/10147/208866
    PubMed ID
    16459497
    Abstract
    Immediate and early trauma death rates are determined by "first hits" such as hypoxia, hypotension and organ injury, while late mortality correlates closely with "second hits" such as infection. An imbalance between the early systemic inflammatory response (SIRS), and the later compensatory counter-inflammatory response (CARS), is considered to be responsible for much post-traumatic morbidity and mortality. From a clinical perspective, this remains a significant healthcare problem, which has stimulated decades of experimental and clinical research aimed at understanding the functional effects of injury on the immune system. This review describes the impact of injury on the innate and adaptive immune systems. Though it is worth noting that the features of the immune response to injury overlap in many areas with immune dysregulation in sepsis, we attempt here to elucidate the mechanism by which injury predisposes to infection rather than to describe the alterations in host immunity consequent to established sepsis.
    Language
    eng
    ISSN
    1479-666X (Print)
    1479-666X (Linking)
    Collections
    Cork University Hospital

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