Affiliation
Department of Surgery, Cork University Hospital, University College Cork,, National University of Ireland. calvincoffey@hotmail.comIssue Date
2012-02-03T15:05:37ZMeSH
HumansNeoplasm, Residual/pathology/surgery
Neoplasms/*pathology/*surgery
Postoperative Period
Risk Factors
Metadata
Show full item recordCitation
Bioessays. 2006 Apr;28(4):433-7.Journal
BioEssays : news and reviews in molecular, cellular and developmental biologyDOI
10.1002/bies.20381PubMed ID
16547958Abstract
In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined "perioperative tumour growth" and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget(1) himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host-tumour interactions that may occur during the perioperative period.Language
engISSN
0265-9247 (Print)0265-9247 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1002/bies.20381
Scopus Count
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