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    Cancer surgery: risks and opportunities.

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    Authors
    Coffey, J C
    Smith, M J F
    Wang, J H
    Bouchier-Hayes, D
    Cotter, T G
    Redmond, H P
    Affiliation
    Department of Surgery, Cork University Hospital, University College Cork,, National University of Ireland. calvincoffey@hotmail.com
    Issue Date
    2012-02-03T15:05:37Z
    MeSH
    Humans
    Neoplasm, Residual/pathology/surgery
    Neoplasms/*pathology/*surgery
    Postoperative Period
    Risk Factors
    
    Metadata
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    Citation
    Bioessays. 2006 Apr;28(4):433-7.
    Journal
    BioEssays : news and reviews in molecular, cellular and developmental biology
    URI
    http://hdl.handle.net/10147/208857
    DOI
    10.1002/bies.20381
    PubMed ID
    16547958
    Abstract
    In the recent past, several papers have pointed to the possibility that tumour removal generates a permissive environment in which tumour growth is potentiated. This phenomenon has been coined "perioperative tumour growth" and whilst it represents a departure in terms of our attitude to the surgical process, this concept was first hinted at by Paget(1) himself. Despite this, the time interval immediately before and after cancer surgery (i.e. the perioperative period) remains an underutilised interval during which chemotherapeutic regimens are rarely implemented. Herein, we present a summarised review of the literature that supports the concept that tumour removal may potentiate the growth of residual neoplastic disease. We also outline current knowledge regarding underlying mechanisms and in this manner highlight potential therapeutic entry points. Finally, we emphasise the urgent need for trials of agents that could protect patients against the harmful host-tumour interactions that may occur during the perioperative period.
    Language
    eng
    ISSN
    0265-9247 (Print)
    0265-9247 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1002/bies.20381
    Scopus Count
    Collections
    Cork University Hospital

    entitlement

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