Co-immunotherapy with interleukin-2 and taurolidine for progressive metastatic melanoma.
Affiliation
Dept of Academic Surgery, Cork University Hospital and NUI.Issue Date
2012-02-03T15:05:28ZMeSH
AdultDrug Combinations
Female
Humans
Immunotherapy
Interleukin-2/*therapeutic use
Ireland
Male
Melanoma/*drug therapy/secondary
Middle Aged
Skin Neoplasms/*drug therapy/*secondary
Taurine/*analogs & derivatives/therapeutic use
Thiadiazines/*therapeutic use
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Ir J Med Sci. 2006 Jan-Mar;175(1):10-4.Journal
Irish journal of medical sciencePubMed ID
16615221Abstract
BACKGROUND: Recombinant interleukin-2(rIL-2) therapy in metastatic melanoma is limited by toxicities, particularly vascular leak syndrome(VLS). Taurolidine potentiates the anti-neoplastic effects of IL-2 while reducing its associated endothelial cell dysfunction in experimental settings. We hypothesized that co-administration of rIL-2 with taurolidine could enhance tolerability without weakening effectiveness. METHODS: Eleven patients with progressive metastatic melanoma received high-dose rIL-2 with co-infusion of taurolidine. Patients were monitored for the development of toxicities and evidence of response. RESULTS: Ten patients tolerated twenty-nine courses of high-dose rIL-2 without dose-reduction. Most toxicities were low-grade. No patient developed VLS. Seven patients died from disease progression. Two had complete clinical and radiological responses to treatment. Two patients remain alive despite evidence of disease progression a mean of 17.5 months after diagnosing metastatic disease. CONCLUSION: Co-administration of taurolidine with high-dose rIL-2 in stage IV melanoma patients appears to greatly enhance the tolerability of this regime without diminishing its therapeutic value.Language
engISSN
0021-1265 (Print)0021-1265 (Linking)
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