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    Weight gain is associated with improved glycaemic control but with adverse changes in plasma lipids and blood pressure isn Type 1 diabetes.

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    Authors
    Ferriss, J B
    Webb, D
    Chaturvedi, N
    Fuller, J H
    Idzior-Walus, B
    Affiliation
    Department of Medicine, Cork University Hospital, Wilton, Cork, Ireland., b.ferriss@ucc.ie
    Issue Date
    2012-02-03T15:05:20Z
    MeSH
    Adolescent
    Adult
    Blood Glucose/*analysis
    Blood Pressure/physiology
    Cholesterol/blood
    Diabetes Mellitus, Type 1/metabolism/*physiopathology
    Drug Administration Schedule
    Female
    Hemoglobin A, Glycosylated/analysis
    Humans
    Hypoglycemic Agents/administration & dosage
    Injections
    Insulin/administration & dosage
    Lipids/*blood
    Lipoproteins/blood
    Male
    Middle Aged
    Prospective Studies
    Triglycerides/blood
    Waist-Hip Ratio
    Weight Gain/*physiology
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    Citation
    Diabet Med. 2006 May;23(5):557-64.
    Journal
    Diabetic medicine : a journal of the British Diabetic Association
    URI
    http://hdl.handle.net/10147/208848
    DOI
    10.1111/j.1464-5491.2006.01847.x
    PubMed ID
    16681565
    Abstract
    AIMS: To assess the effects of weight gain on metabolic control, plasma lipids and blood pressure in patients with Type 1 diabetes. METHODS: Patients in the EURODIAB Prospective Complications Study (n = 3250) were examined at baseline and 1800 (55%) were re-examined a mean of 7.3 years later. Patients had Type 1 diabetes, defined as a diagnosis made before age 36 years and with a need for continuous insulin therapy within a year of diagnosis. Patients were aged 15-60 years at baseline and were stratified for age, sex and duration of diabetes. RESULTS: The change in HbA(1c) from baseline to follow-up examination was significantly more favourable in those who gained 5 kg or more during follow-up ('marked weight gain') than in patients who gained less or no weight or lost weight ('less or no weight gain'). In those with marked weight gain, there was a significantly greater rise in plasma triglycerides and total cholesterol and significantly less favourable changes in low-density lipoprotein and high-density lipoprotein cholesterol compared with those with less or no weight gain, with or without adjustment for HbA(1c). Systolic and diastolic blood pressure also rose significantly more in the group with marked weight gain. CONCLUSION: Weight gain in patients with Type 1 diabetes has adverse effects on plasma lipids and blood pressure, despite a small improvement in glycaemic control.
    Language
    eng
    ISSN
    0742-3071 (Print)
    0742-3071 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1464-5491.2006.01847.x
    Scopus Count
    Collections
    Cork University Hospital

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