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    Comparison of three stool antigen assays with the 13C- urea breath test for the primary diagnosis of Helicobacter pylori infection and monitoring treatment outcome.

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    Authors
    Hooton, Carmel
    Keohane, John
    Clair, Jim
    Azam, Mohammad
    O'Mahony, Seamus
    Crosbie, Orla
    Lucey, Brigid
    Affiliation
    Cork University Hospital, Cork, Ireland. hootonc@shb.ie
    Issue Date
    2012-02-03T15:05:16Z
    MeSH
    Adult
    Antigens, Bacterial/*analysis
    *Breath Tests
    Carbon Isotopes/diagnostic use
    Dyspepsia/etiology
    Feces/*microbiology
    Female
    Helicobacter Infections/*diagnosis
    Helicobacter pylori/*immunology
    Humans
    Male
    Middle Aged
    Sensitivity and Specificity
    Urea/diagnostic use
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    Citation
    Eur J Gastroenterol Hepatol. 2006 Jun;18(6):595-9.
    Journal
    European journal of gastroenterology & hepatology
    URI
    http://hdl.handle.net/10147/208846
    PubMed ID
    16702847
    Abstract
    BACKGROUND: The urea breath test (UBT) is the gold-standard non-invasive test for the detection of Helicobacter pylori infection, however, the lack of availability of the UBT due to the high cost of the test, and in particular the need for expensive analytical instrumentation, limits the usefulness of this method. Stool antigen assays may offer an alternative non-invasive method for the diagnosis of infection. OBJECTIVE: To compare the accuracy of three stool antigen assays (HpSA, IDEIA HpStAR, and ImmunoCard STAT) against the UBT for the primary diagnosis of H. pylori infection and for monitoring treatment outcome. METHODS: A total of 102 patients attending two gastroenterology day-case clinics for the investigation of dyspepsia were included. Each patient provided breath and stool samples for analysis. Patients who tested positive for H. pylori by the validated UBT were prescribed triple therapy and invited to return for repeat breath and stool sample analysis 6 weeks post-treatment. RESULTS: Of the 102 patients tested, 48 were diagnosed with H. pylori infection by the UBT. The HpSA assay interpreted 38 of these as positive (79% sensitive). Of the 54 UBT-negative patients the HpSA assay interpreted all 54 as negative (100% specific). The IDEIA HpStAR assay correctly identified 44 patients as positive (92% sensitive) and 50 as negative (92.5% specific). The ImmunoCard STAT assay interpreted 38 patients as positive (79% sensitive) and 52 as negative (96.3% specific). CONCLUSION: The findings indicate that the IDEIA HpStAR stool antigen kit is the most accurate assay of the three assays evaluated, and possibly represents a viable alternative to the UBT for the primary diagnosis of H. pylori infection and for monitoring treatment outcome.
    Language
    eng
    ISSN
    0954-691X (Print)
    0954-691X (Linking)
    Collections
    Cork University Hospital

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