Functional dyspepsia: the role of visceral hypersensitivity in its pathogenesis.
AffiliationDepartment of Medicine, Alimentary Pharmabiotic Centre, Clinical Sciences, Building, Cork University Hospital, Cork, Ireland.
Central Nervous System/drug effects/physiopathology
Efferent Pathways/drug effects/physiopathology
Enteric Nervous System/drug effects/physiopathology
MetadataShow full item record
CitationWorld J Gastroenterol. 2006 May 7;12(17):2672-6.
JournalWorld journal of gastroenterology : WJG
AbstractFunctional, or non-ulcer, dyspepsia (FD) is one of the most common reasons for referral to gastroenterologists. It is associated with significant morbidity and impaired quality of life. Many authorities believe that functional dyspepsia and irritable bowel syndrome represent part of the spectrum of the same disease process. The pathophysiology of FD remains unclear but several theories have been proposed including visceral hypersensitivity, gastric motor dysfunction, Helicobacter pylori infection and psychosocial factors. In this review, we look at the evidence, to date, for the role of visceral hypersensitivity in the aetiology of FD.