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    Cytokine orchestration in post-operative peritoneal adhesion formation.

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    Authors
    Cahill, Ronan A
    Redmond, H Paul
    Affiliation
    Department of General Surgery, Cork University Hospital, Wilton, Cork, Ireland., rcahill@rcsi.ie
    Issue Date
    2012-02-03T15:05:05Z
    MeSH
    Biomedical Research
    Cytokines/antagonists & inhibitors/*metabolism
    Drugs, Investigational/therapeutic use
    Humans
    Laparotomy/*adverse effects
    Peritoneal Diseases/drug therapy/etiology/*immunology/pathology
    Tissue Adhesions
    Treatment Outcome
    
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    Citation
    World J Gastroenterol. 2008 Aug 21;14(31):4861-6.
    Journal
    World journal of gastroenterology : WJG
    URI
    http://hdl.handle.net/10147/208840
    PubMed ID
    18756592
    Abstract
    Peritoneal adhesions are a near inevitable occurrence after laparotomy and a major cause of both patient and physician misery. To date, clinical attempts at their amelioration have concentrated on manipulating the physical factors that affect their development despite a wealth of experimental data elucidating the molecular mechanisms that underlie their initiation, development and maturation. However, the advent of targeted, specific anti-cytokine agents as directed therapy for inflammatory and neoplastic conditions raises the prospect of a new era for anti-adhesion strategies. To harness this potential will require considerable cross-disciplinary collaboration and that surgeon-scientists propel themselves to the forefront of this emerging field.
    Language
    eng
    ISSN
    1007-9327 (Print)
    1007-9327 (Linking)
    Collections
    Cork University Hospital

    entitlement

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