Plasma cytokine profiles in depressed patients who fail to respond to selective serotonin reuptake inhibitor therapy.
AffiliationAlimentary Pharmabiotic Centre and Department of Psychiatry, Cork University, Hospital, Wilton, Cork, Ireland.
Analysis of Variance
Antidepressive Agents/*therapeutic use
Depressive Disorder, Major/*blood/drug therapy
Enzyme-Linked Immunosorbent Assay/methods
Psychiatric Status Rating Scales
Serotonin Uptake Inhibitors/*therapeutic use
MetadataShow full item record
CitationJ Psychiatr Res. 2007 Apr-Jun;41(3-4):326-31. Epub 2006 Jul 25.
JournalJournal of psychiatric research
AbstractOBJECTIVE: Approximately 30% of patients with depression fail to respond to a selective serotonin reuptake inhibitor (SSRI). Few studies have attempted to define these patients from a biological perspective. Studies suggest that overall patients with depression show increased production of proinflammatory cytokines. We examined pro- and anti-inflammatory cytokine levels in patients who were SSRI resistant. METHODS: Plasma concentrations of IL-6, IL-8, IL-10, TNF-alpha and sIL-6R were measured with enzyme linked immunosorbent assays (ELISA) in DSM-1V major depressives who were SSRI resistant, in formerly SSRI resistant patients currently euthymic and in healthy controls. RESULTS: Patients with SSRI-resistant depression had significantly higher production of the pro-inflammatory cytokines IL-6 (p=0.01) and TNF-alpha (p=0.004) compared to normal controls. Euthymic patients who were formerly SSRI resistant had proinflammatory cytokine levels which were similar to the healthy subject group. Anti-inflammatory cytokine levels did not differ across the 3 groups. CONCLUSION: Suppression of proinflammatory cytokines does not occur in depressed patients who fail to respond to SSRIs and is necessary for clinical recovery.