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Cellular reprogramming by gram-positive bacterial components: a review.

dc.contributor.authorBuckley, Julliette M
dc.contributor.authorWang, Jiang Huai
dc.contributor.authorRedmond, H Paul
dc.date.accessioned2012-02-03T15:04:42Z
dc.date.available2012-02-03T15:04:42Z
dc.date.issued2012-02-03T15:04:42Z
dc.identifier.citationJ Leukoc Biol. 2006 Oct;80(4):731-41. Epub 2006 Aug 2.en_GB
dc.identifier.issn0741-5400 (Print)en_GB
dc.identifier.issn0741-5400 (Linking)en_GB
dc.identifier.pmid16885502en_GB
dc.identifier.doi10.1189/jlb.0506312en_GB
dc.identifier.urihttp://hdl.handle.net/10147/208828
dc.description.abstractLPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.
dc.language.isoengen_GB
dc.subject.meshAnimalsen_GB
dc.subject.meshCytokines/biosynthesis/drug effectsen_GB
dc.subject.meshGram-Positive Bacteria/*immunologyen_GB
dc.subject.meshHumansen_GB
dc.subject.meshImmune Tolerance/immunologyen_GB
dc.subject.meshLipopolysaccharides/immunology/*pharmacologyen_GB
dc.subject.meshLipoproteins/*pharmacologyen_GB
dc.subject.meshReceptors, Cell Surface/biosynthesis/*drug effects/immunologyen_GB
dc.subject.meshSignal Transduction/*drug effects/immunologyen_GB
dc.subject.meshTeichoic Acids/*pharmacologyen_GB
dc.titleCellular reprogramming by gram-positive bacterial components: a review.en_GB
dc.contributor.departmentDepartment of Academic Surgery, Cork University Hospital, National University of , Ireland/University College Cork, Wilton, Cork, Ireland.en_GB
dc.identifier.journalJournal of leukocyte biologyen_GB
dc.description.provinceMunster
html.description.abstractLPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.


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