Cellular reprogramming by gram-positive bacterial components: a review.
Affiliation
Department of Academic Surgery, Cork University Hospital, National University of , Ireland/University College Cork, Wilton, Cork, Ireland.Issue Date
2012-02-03T15:04:42ZMeSH
AnimalsCytokines/biosynthesis/drug effects
Gram-Positive Bacteria/*immunology
Humans
Immune Tolerance/immunology
Lipopolysaccharides/immunology/*pharmacology
Lipoproteins/*pharmacology
Receptors, Cell Surface/biosynthesis/*drug effects/immunology
Signal Transduction/*drug effects/immunology
Teichoic Acids/*pharmacology
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J Leukoc Biol. 2006 Oct;80(4):731-41. Epub 2006 Aug 2.Journal
Journal of leukocyte biologyDOI
10.1189/jlb.0506312PubMed ID
16885502Abstract
LPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.Language
engISSN
0741-5400 (Print)0741-5400 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1189/jlb.0506312
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