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    Cellular reprogramming by gram-positive bacterial components: a review.

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    Authors
    Buckley, Julliette M
    Wang, Jiang Huai
    Redmond, H Paul
    Affiliation
    Department of Academic Surgery, Cork University Hospital, National University of , Ireland/University College Cork, Wilton, Cork, Ireland.
    Issue Date
    2012-02-03T15:04:42Z
    MeSH
    Animals
    Cytokines/biosynthesis/drug effects
    Gram-Positive Bacteria/*immunology
    Humans
    Immune Tolerance/immunology
    Lipopolysaccharides/immunology/*pharmacology
    Lipoproteins/*pharmacology
    Receptors, Cell Surface/biosynthesis/*drug effects/immunology
    Signal Transduction/*drug effects/immunology
    Teichoic Acids/*pharmacology
    
    Metadata
    Show full item record
    Citation
    J Leukoc Biol. 2006 Oct;80(4):731-41. Epub 2006 Aug 2.
    Journal
    Journal of leukocyte biology
    URI
    http://hdl.handle.net/10147/208828
    DOI
    10.1189/jlb.0506312
    PubMed ID
    16885502
    Abstract
    LPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.
    Language
    eng
    ISSN
    0741-5400 (Print)
    0741-5400 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1189/jlb.0506312
    Scopus Count
    Collections
    Cork University Hospital

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