Cellular reprogramming by gram-positive bacterial components: a review.
AffiliationDepartment of Academic Surgery, Cork University Hospital, National University of , Ireland/University College Cork, Wilton, Cork, Ireland.
Receptors, Cell Surface/biosynthesis/*drug effects/immunology
Signal Transduction/*drug effects/immunology
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CitationJ Leukoc Biol. 2006 Oct;80(4):731-41. Epub 2006 Aug 2.
JournalJournal of leukocyte biology
AbstractLPS tolerance has been the focus of extensive scientific and clinical research over the last several decades in an attempt to elucidate the sequence of changes that occur at a molecular level in tolerized cells. Tolerance to components of gram-positive bacterial cell walls such as bacterial lipoprotein and lipoteichoic acid is a much lesser studied, although equally important, phenomenon. This review will focus on cellular reprogramming by gram-positive bacterial components and examines the alterations in cell surface receptor expression, changes in intracellular signaling, gene expression and cytokine production, and the phenomenon of cross-tolerance.