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    Exploitation of the Toll-like receptor system in cancer: a doubled-edged sword?

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    Authors
    Killeen, S D
    Wang, J H
    Andrews, E J
    Redmond, H P
    Affiliation
    Department of Academic Surgery, National University of Ireland (NUI)/University, College Cork (UCC), Cork University Hospital, Cork, Ireland.
    Issue Date
    2012-02-03T15:04:38Z
    MeSH
    Disease Progression
    Humans
    Immunotherapy
    Models, Immunological
    Neoplasms/*immunology/therapy
    Signal Transduction/immunology
    Toll-Like Receptors/*immunology
    
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    Citation
    Br J Cancer. 2006 Aug 7;95(3):247-52.
    Journal
    British journal of cancer
    URI
    http://hdl.handle.net/10147/208826
    DOI
    10.1038/sj.bjc.6603275
    PubMed ID
    16892041
    Abstract
    The toll-like receptor (TLR) system constitutes a pylogenetically ancient, evolutionary conserved, archetypal pattern recognition system, which underpins pathogen recognition by and activation of the immune system. Toll-like receptor agonists have long been used as immunoadjuvants in anti cancer immunotherapy. However, TLRs are increasingly implicated in human disease pathogenesis and an expanding body of both clinical and experimental evidence suggests that the neoplastic process may subvert TLR signalling pathways to advance cancer progression. Recent discoveries in the TLR system open a multitude of potential therapeutic avenues. Extrapolation of such TLR system manipulations to a clinical oncological setting demands care to prevent potentially deleterious activation of TLR-mediated survival pathways. Thus, the TLR system is a double-edge sword, which needs to be carefully wielded in the setting of neoplastic disease.
    Language
    eng
    ISSN
    0007-0920 (Print)
    0007-0920 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1038/sj.bjc.6603275
    Scopus Count
    Collections
    Cork University Hospital

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