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    Mobilization of endothelial precursor cells: systemic vascular response to musculoskeletal trauma.

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    Authors
    Laing, A J
    Dillon, J P
    Condon, E T
    Street, J T
    Wang, J H
    McGuinness, A J
    Redmond, H P
    Affiliation
    Departments of Surgical Research and Orthopaedic Surgery, Cork University, Hospital, Cork, Ireland. alanjlaing@hotmail.com
    Issue Date
    2012-02-03T15:04:23Z
    MeSH
    Adult
    Antigens, CD34/physiology
    Cell Differentiation
    Endothelial Cells/cytology
    Endothelium, Vascular/*cytology
    Female
    Humans
    Leukocytes, Mononuclear/immunology/physiology
    Male
    Middle Aged
    Neovascularization, Physiologic/*physiology
    Stem Cells/*cytology
    Tibial Fractures/*physiopathology
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    Citation
    J Orthop Res. 2007 Jan;25(1):44-50.
    Journal
    Journal of orthopaedic research : official publication of the Orthopaedic, Research Society
    URI
    http://hdl.handle.net/10147/208819
    DOI
    10.1002/jor.20228
    PubMed ID
    17001704
    Abstract
    Postnatal vasculogenesis, the process by which vascular committed bone marrow stem cells or endothelial precursor cells (EPC) migrate, differentiate, and incorporate into the nacent endothelium contributing to physiological and pathological neovascularization, has stimulated much interest. Its contribution to tumor nonvascularization, wound healing, and revascularization associated with skeletal and cardiac muscles ischaemia is established. We evaluated the mobilization of EPCs in response to musculoskeletal trauma. Blood from patients (n = 15) following AO type 42a1 closed diaphyseal tibial fractures was analyzed for CD34 and AC133 cell surface marker expression. Immunomagnetically enriched CD34+ mononuclear cell (MNC(CD34+)) populations were cultured and examined for phenotypic and functional vascular endothelial differentiation. Circulating MNC(CD34+) levels increased sevenfold by day 3 postinjury. Circulating MNC(AC133+) increased 2.5-fold. Enriched MNC(CD34+) populations from day 3 samples in culture exhibited cell cluster formation with sprouting spindles. These cells bound UEA-1 and incorporated fluorescent DiI-Ac-LDL intracellularily. Our findings suggest a systemic provascular response is initiated in response to musculoskeletal trauma. Its therapeutic manipulation may have implications for the potential enhancement of fracture healing.
    Language
    eng
    ISSN
    0736-0266 (Print)
    0736-0266 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1002/jor.20228
    Scopus Count
    Collections
    Cork University Hospital

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