Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.
Authors
Cleary, Brian JButt, Hajeera
Strawbridge, Judith D
Gallagher, Paul J
Fahey, Tom
Murphy, Deirdre J
Affiliation
Coombe Women and Infants University Hospital, Dublin, Republic of Ireland., bcleary@coombe.ieIssue Date
2012-02-01T10:58:34ZMeSH
AdultCohort Studies
Drug Utilization Review/*statistics & numerical data
Female
Fetal Development/drug effects
Gestational Age
Humans
*Pharmaceutical Preparations/administration & dosage/adverse
effects/classification
Plant Preparations/administration & dosage/adverse effects/therapeutic use
Pregnancy
Pregnancy Complications/*drug therapy/epidemiology/etiology
Prescription Drugs/administration & dosage/adverse effects/therapeutic use
Prevalence
Prospective Studies
Questionnaires
Street Drugs/adverse effects
United States
United States Food and Drug Administration
Young Adult
Metadata
Show full item recordCitation
Pharmacoepidemiol Drug Saf. 2010 Apr;19(4):408-17.Journal
Pharmacoepidemiology and drug safetyDOI
10.1002/pds.1906PubMed ID
20099251Abstract
PURPOSE: To examine the extent, nature and determinants of medication use in early pregnancy. METHODS: We reviewed early pregnancy medication use, as reported to a midwife at the booking interview, in women delivering between 2000 and 2007 in a large maternity hospital in Dublin, Ireland (n = 61 252). RESULTS: Excluding folic acid, at least one medication was reported in 23 989 (39.2%) pregnancies. Over the counter (OTC) medications were reported in 11 970 (19.5%) pregnancies, illicit drugs or methadone in 545 (0.9%) and herbal medicines/supplements in 352 (0.58%). FDA category D and X medications were reported by 1532 (2.5%) and 1987 (3.2%) women. Asthma, depression and hypertension were among the most commonly reported chronic medical disorders. Medications with potential for foetal harm were reported by 86 (15.7%) women treated for depression and 68 (20%) women treated for hypertension. Factors associated with reporting the use of medications with potential for foetal harm included unplanned pregnancy (adjusted odds ratio [aOR] 1.31, 95% confidence interval [CI] 1.12-1.52), booking at less than 12 weeks gestation (aOR 1.83, 95%CI 1.58-2.13), being above 25 years of age, unemployed (aOR 2.58, 95%CI 2.03-3.29), nulliparous (aOR 1.41; 95%CI 1.22-1.63), single (aOR 1.28; 95%CI 1.06-1.54) or smoking during pregnancy (aOR 1.96, 95%CI 1.67-2.28). CONCLUSIONS: Women frequently report medication use in early pregnancy. Women and prescribers need to be aware of the lack of pregnancy safety data for many medications, and the need for pre-pregnancy planning. Prescribers should ensure that optimal medications are used when treating women of childbearing potential with chronic medical disorders.Language
engISSN
1099-1557 (Electronic)1053-8569 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1002/pds.1906
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