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    Medication use in early pregnancy-prevalence and determinants of use in a prospective cohort of women.

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    Authors
    Cleary, Brian J
    Butt, Hajeera
    Strawbridge, Judith D
    Gallagher, Paul J
    Fahey, Tom
    Murphy, Deirdre J
    Affiliation
    Coombe Women and Infants University Hospital, Dublin, Republic of Ireland., bcleary@coombe.ie
    Issue Date
    2012-02-01T10:58:34Z
    MeSH
    Adult
    Cohort Studies
    Drug Utilization Review/*statistics & numerical data
    Female
    Fetal Development/drug effects
    Gestational Age
    Humans
    *Pharmaceutical Preparations/administration & dosage/adverse
    effects/classification
    Plant Preparations/administration & dosage/adverse effects/therapeutic use
    Pregnancy
    Pregnancy Complications/*drug therapy/epidemiology/etiology
    Prescription Drugs/administration & dosage/adverse effects/therapeutic use
    Prevalence
    Prospective Studies
    Questionnaires
    Street Drugs/adverse effects
    United States
    United States Food and Drug Administration
    Young Adult
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    Citation
    Pharmacoepidemiol Drug Saf. 2010 Apr;19(4):408-17.
    Journal
    Pharmacoepidemiology and drug safety
    URI
    http://hdl.handle.net/10147/208043
    DOI
    10.1002/pds.1906
    PubMed ID
    20099251
    Abstract
    PURPOSE: To examine the extent, nature and determinants of medication use in early pregnancy. METHODS: We reviewed early pregnancy medication use, as reported to a midwife at the booking interview, in women delivering between 2000 and 2007 in a large maternity hospital in Dublin, Ireland (n = 61 252). RESULTS: Excluding folic acid, at least one medication was reported in 23 989 (39.2%) pregnancies. Over the counter (OTC) medications were reported in 11 970 (19.5%) pregnancies, illicit drugs or methadone in 545 (0.9%) and herbal medicines/supplements in 352 (0.58%). FDA category D and X medications were reported by 1532 (2.5%) and 1987 (3.2%) women. Asthma, depression and hypertension were among the most commonly reported chronic medical disorders. Medications with potential for foetal harm were reported by 86 (15.7%) women treated for depression and 68 (20%) women treated for hypertension. Factors associated with reporting the use of medications with potential for foetal harm included unplanned pregnancy (adjusted odds ratio [aOR] 1.31, 95% confidence interval [CI] 1.12-1.52), booking at less than 12 weeks gestation (aOR 1.83, 95%CI 1.58-2.13), being above 25 years of age, unemployed (aOR 2.58, 95%CI 2.03-3.29), nulliparous (aOR 1.41; 95%CI 1.22-1.63), single (aOR 1.28; 95%CI 1.06-1.54) or smoking during pregnancy (aOR 1.96, 95%CI 1.67-2.28). CONCLUSIONS: Women frequently report medication use in early pregnancy. Women and prescribers need to be aware of the lack of pregnancy safety data for many medications, and the need for pre-pregnancy planning. Prescribers should ensure that optimal medications are used when treating women of childbearing potential with chronic medical disorders.
    Language
    eng
    ISSN
    1099-1557 (Electronic)
    1053-8569 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1002/pds.1906
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

    entitlement

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