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    Human papillomavirus vaccination in the prevention of cervical neoplasia.

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    Authors
    Astbury, Katharine
    Turner, Michael J
    Affiliation
    Department of Obstetrics and Gynaecology, Coombe Women's Hospital, Dublin,, Ireland. kathastbury@gmail.com
    Issue Date
    2012-02-01T10:58:21Z
    MeSH
    Cervical Intraepithelial Neoplasia/etiology/immunology/*prevention & control
    Female
    Humans
    Immunity, Active/physiology
    Male
    Papillomavirus Infections/complications/immunology/*prevention & control
    Papillomavirus Vaccines/biosynthesis/immunology/*therapeutic use
    Treatment Outcome
    Uterine Cervical Neoplasms/etiology/immunology/*prevention & control
    *Vaccination/economics/methods
    
    Metadata
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    Citation
    Int J Gynecol Cancer. 2009 Dec;19(9):1610-3.
    Journal
    International journal of gynecological cancer : official journal of the, International Gynecological Cancer Society
    URI
    http://hdl.handle.net/10147/208035
    DOI
    10.1111/IGC.0b013e3181a8411b
    PubMed ID
    19955947
    Abstract
    Cervical cancer remains a major cause of morbidity and mortality for women worldwide. Although the introduction of comprehensive screening programs has reduced the disease incidence in developed countries, it remains a major problem in the developing world. The recent licensing of 2 vaccines against human papillomavirus (HPV) type 16 and HPV-18, the viruses responsible for 70% of cervical cancer cases, offers the hope of disease prevention. In this article, we review the role of HPV in the etiology of cervical cancer and the evidence to support the introduction of vaccination programs in young women and discuss the potential obstacles to widespread vaccination. In addition, we discuss the issues that remain to be elucidated, including the potential need for booster doses of the vaccine and the role of concomitant vaccination in men.
    Language
    eng
    ISSN
    1525-1438 (Electronic)
    1048-891X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/IGC.0b013e3181a8411b
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

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