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    The treatment of CIN: what are the risks?

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    Authors
    Prendiville, W
    Affiliation
    Royal College of Surgeons in Ireland, Department of Gynaecology, Coombe and, Tallagh Hospital, Dublin, Ireland. walter.prendiville@gmail.com
    Issue Date
    2012-02-01T10:58:06Z
    MeSH
    Biopsy/methods
    Cervical Intraepithelial Neoplasia/pathology/*surgery
    Colposcopy/*adverse effects
    Female
    Guidelines as Topic
    Humans
    Obstetric Labor, Premature/etiology
    Pregnancy
    Risk Factors
    Uterine Cervical Neoplasms/pathology/*surgery
    
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    Show full item record
    Citation
    Cytopathology. 2009 Jun;20(3):145-53.
    Journal
    Cytopathology : official journal of the British Society for Clinical Cytology
    URI
    http://hdl.handle.net/10147/208027
    DOI
    10.1111/j.1365-2303.2009.00669.x
    PubMed ID
    19489986
    Abstract
    The treatment of CIN: what are the risks?The treatment of squamous cervical intraepithelial neoplasia is to remove or destroy the transformation zone (TZ). It is likely that no method of treatment is superior to another if it is performed properly and the limited available evidence supports this view. The significant advantages of excision (simplicity, cost, outpatient procedure, histological examination of the entire TZ) mean that treatment thresholds may have lowered over the last decade. Long-term pregnancy-related morbidity associated with excision has been reported recently. The evidence would suggest that this increase equates to a genuine increase in serious adverse outcome for cone biopsy but not large loop excision of the transformation zone (LLETZ). The available data also point to an increase in both incomplete excision and premature labour associated with the excision of large endocervical TZs. The clinical implications arising from this are firstly that women with large type 2 and 3 TZs need appropriate counselling before treatment and that the threshold for treating young women with mild abnormalities needs review.
    Language
    eng
    ISSN
    1365-2303 (Electronic)
    0956-5507 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2303.2009.00669.x
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

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