AffiliationPharmacy Department, Coombe Women and Infants University Hospital, Dublin 8,, Ireland. firstname.lastname@example.org
Anti-Inflammatory Agents/*adverse effects
Inflammatory Bowel Diseases/drug therapy
MetadataShow full item record
CitationBirth Defects Res A Clin Mol Teratol. 2009 Jul;85(7):647-54.
JournalBirth defects research. Part A, Clinical and molecular teratology
AbstractBACKGROUND: Azathioprine (AZA) is used during pregnancy by women with inflammatory bowel disease (IBD), other autoimmune disorders, malignancy, and organ transplantation. Previous studies have demonstrated potential risks. METHODS: The Swedish Medical Birth Register was used to identify 476 women who reported the use of AZA in early pregnancy. The effect of AZA exposure on pregnancy outcomes was studied after adjustment for maternal characteristics that could act as confounders. RESULTS: The most common indication for AZA use was IBD. The rate of congenital malformations was 6.2% in the AZA group and 4.7% among all infants born (adjusted OR: 1.41, 95% CI: 0.98-2.04). An association between early pregnancy AZA exposure and ventricular/atrial septal defects was found (adjusted OR: 3.18, 95% CI: 1.45-6.04). Exposed infants were also more likely to be preterm, to weigh <2500 gm, and to be small for gestational age compared to all infants born. This effect remained for preterm birth and low birth weight when infants of women with IBD but without AZA exposure were used as a comparison group. A trend toward an increased risk of congenital malformations was found among infants of women with IBD using AZA compared to women with IBD not using AZA (adjusted OR: 1.42, 95% CI: 0.93-2.18). CONCLUSIONS: Infants exposed to AZA in early pregnancy may be at a moderately increased risk of congenital malformations, specifically ventricular/atrial septal defects. There is also an increased risk of growth restriction and preterm delivery. These associations may be confounded by the severity of maternal illness.
- Outcomes of infants born to mothers with inflammatory bowel disease: a population-based cohort study.
- Authors: Dominitz JA, Young JC, Boyko EJ
- Issue date: 2002 Mar
- Use of benzodiazepines and benzodiazepine receptor agonists during pregnancy: neonatal outcome and congenital malformations.
- Authors: Wikner BN, Stiller CO, Bergman U, Asker C, Källén B
- Issue date: 2007 Nov
- Therapeutic drug use in women with Crohn's disease and birth outcomes: a Danish nationwide cohort study.
- Authors: Nørgård B, Pedersen L, Christensen LA, Sørensen HT
- Issue date: 2007 Jul
- Birth outcome in women treated with azathioprine or mercaptopurine during pregnancy: A Danish nationwide cohort study.
- Authors: Langagergaard V, Pedersen L, Gislum M, Nørgard B, Sørensen HT
- Issue date: 2007 Jan 1
- Pregnancy outcome after maternal organ transplantation in Sweden.
- Authors: Källén B, Westgren M, Aberg A, Olausson PO
- Issue date: 2005 Jul