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    Prevalence and predictors of periconceptional folic acid uptake--prospective cohort study in an Irish urban obstetric population.

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    Authors
    McGuire, M
    Cleary, B
    Sahm, L
    Murphy, D J
    Affiliation
    Coombe Women and Infants University Hospital, Dolphins Barn, Dublin 8, Ireland.
    Issue Date
    2012-02-01T10:57:52Z
    MeSH
    Adult
    Cohort Studies
    Female
    Folic Acid/administration & dosage/*metabolism
    Humans
    Ireland/epidemiology
    Neural Tube Defects/*epidemiology
    Pregnancy
    Prevalence
    Socioeconomic Factors
    Urban Health
    *Urban Population
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    Metadata
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    Citation
    Hum Reprod. 2010 Feb;25(2):535-43. Epub 2009 Nov 12.
    Journal
    Human reproduction (Oxford, England)
    URI
    http://hdl.handle.net/10147/208019
    DOI
    10.1093/humrep/dep398
    PubMed ID
    19910320
    Abstract
    BACKGROUND: Neural tube defects (NTDs) are severe abnormalities of the central nervous system that occur as a result of abnormal development in the third and fourth weeks of gestation. Studies have shown that periconceptional folic acid (FA) can reduce both the incidence and recurrence of NTDs. METHODS: A cohort study was carried out using the electronic hospital booking records of women delivering in a large Dublin maternity hospital between 2000 and 2007. Logistic regression analyses were performed to measure the associations between maternal factors and optimal FA use. RESULTS: Of the 61,252 women in the cohort, 85% reported taking FA at some point during the periconceptional period; however, only 28% took FA as recommended. Factors associated with taking the recommended amount of FA included nulliparity [adjusted OR: 1.35 (95% CI: 1.28-1.43)], early booking (<12 weeks) [OR: 1.24 (95% CI: 1.17-1.31)], increasing maternal age (e.g. 30-34 years) [OR: 1.39 (95% CI: 1.30-1.48)], private health care [OR: 4.32 (95% CI: 4.1-4.6)] and fertility treatment [OR: 2.88 (95% CI: 2.44-3.40)]. Factors associated with taking less than recommended or no FA included unplanned pregnancy [OR: 0.08 (0.07-0.08)], lower socio-economic status (e.g. unemployed) [OR: 0.63 (95% CI: 0.55-0.71)], non-Irish nationality [OR: 0.82 (0.74-0.90)] and smokers [OR: 0.51 (95% CI: 0.47-0.55)]. CONCLUSIONS: Social, demographic and economic factors have an important influence on the FA uptake. Vulnerable groups who report limited uptake of FA need to be specifically targeted in future Public Health campaigns and further consideration needs to be given to the debate on food fortification in countries where this is currently not available.
    Language
    eng
    ISSN
    1460-2350 (Electronic)
    0268-1161 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1093/humrep/dep398
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

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