Cerebral tissue oxygenation index and superior vena cava blood flow in the very low birth weight infant.
AffiliationDepartment of Pediatrics and Newborn Medicine, Coombe Women and Infants, University Hospital, Dublin 8, Ireland.
Cerebral Ventricles/blood supply
*Infant, Very Low Birth Weight
Regional Blood Flow
*Vena Cava, Superior
MetadataShow full item record
CitationActa Paediatr. 2009 Jan;98(1):43-6. Epub 2008 Oct 6.
JournalActa paediatrica (Oslo, Norway : 1992)
AbstractBACKGROUND: Superior vena cava (SVC) flow assesses blood flow from the upper body, including the brain. Near infrared spectroscopy (NIRS) provides information on brain perfusion and oxygenation. AIM: To assess the relationship between cerebral tissue oxygenation index (cTOI) and cardiac output measures in the very low birth weight (VLBW) infant in the first day of life. METHODS: A prospective observational cohort study. Neonates with birth weight less than 1500 g (VLBW) were eligible for enrollment. Newborns with congenital heart disease, major congenital malformations and greater than Papile grade1 Intraventricular Haemorrhage on day 1 of life were excluded. Echocardiographic evaluation of SVC flow was performed in the first 24 h of life. Low SVC flow states were defined as a flow less than 40 mL/kg/min. cTOI was measured using NIRO 200 Hamamatsu. RESULTS: Twenty-seven VLBW neonates had both echocardiography and NIRS performed. The median (range) gestation was 29/40 (25 + 3 to 31 + 5 weeks) and median birth weight was 1.2 kg (0.57-1.48 kg). The mean (SD) TOI was 68.1 (7.9)%. The mean (SD) SVC flow was 70.36(39.5) mLs/kg/min. The correlation coefficient of cerebral tissue oxygenation and SVC flow was r = 0.53, p-value 0.005. There was a poor correlation between right and left ventricular output and cTOI which is not surprising considering the influence of intra- and extracardiac shunts. CONCLUSION: There is a positive relationship between cerebral TOI values and SVC flow in the very low birth infant on day one of life.
- Cerebral tissue oxygenation index, cardiac output and superior vena cava flow in infants with birth weight less than 1250 grams in the first 48 hours of life.
- Authors: Sirc J, Dempsey EM, Miletin J
- Issue date: 2013 Jul
- Effects of surgical repair of congenital diaphragmatic hernia on cerebral hemodynamics evaluated by near-infrared spectroscopy.
- Authors: Dotta A, Rechichi J, Campi F, Braguglia A, Palamides S, Capolupo I, Lozzi S, Trucchi A, Corchia C, Bagolan P, Orzalesi M
- Issue date: 2005 Nov
- Low superior vena cava flow on day 1 and adverse outcome in the very low birthweight infant.
- Authors: Miletin J, Dempsey EM
- Issue date: 2008 Sep
- Near-infrared spectroscopic cerebral oxygenation reading in neonates and infants is associated with central venous oxygen saturation.
- Authors: Weiss M, Dullenkopf A, Kolarova A, Schulz G, Frey B, Baenziger O
- Issue date: 2005 Feb
- Umbilical cord milking stabilizes cerebral oxygenation and perfusion in infants born before 29 weeks of gestation.
- Authors: Takami T, Suganami Y, Sunohara D, Kondo A, Mizukaki N, Fujioka T, Hoshika A, Akutagawa O, Isaka K
- Issue date: 2012 Oct