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    Methadone and perinatal outcomes: a retrospective cohort study.

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    Authors
    Cleary, Brian J
    Donnelly, Jean M
    Strawbridge, Judith D
    Gallagher, Paul J
    Fahey, Tom
    White, Martin J
    Murphy, Deirdre J
    Affiliation
    Department of Obstetrics and Gynecology, Trinity College Dublin, Royal College of, Surgeons in Ireland, Dublin, Republic of Ireland. bcleary@coombe.ie
    Issue Date
    2012-02-01T10:57:19Z
    MeSH
    Age Factors
    Dose-Response Relationship, Drug
    Female
    Humans
    Infant, Newborn
    Methadone/*adverse effects/therapeutic use
    Narcotics/adverse effects/therapeutic use
    Neonatal Abstinence Syndrome/diagnosis/*etiology
    Odds Ratio
    *Opiate Substitution Treatment
    Opioid-Related Disorders/*rehabilitation
    Pregnancy
    Premature Birth/*etiology
    Retrospective Studies
    Risk Factors
    Smoking
    Treatment Outcome
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    Citation
    Am J Obstet Gynecol. 2011 Feb;204(2):139.e1-9. Epub 2010 Dec 8.
    Journal
    American journal of obstetrics and gynecology
    URI
    http://hdl.handle.net/10147/208001
    DOI
    10.1016/j.ajog.2010.10.004
    PubMed ID
    21145035
    Abstract
    OBJECTIVE: The purpose of this study was to examine the relationship among methadone maintenance treatment, perinatal outcomes, and neonatal abstinence syndrome. STUDY DESIGN: This was a retrospective cohort study of 61,030 singleton births at a large maternity hospital from 2000-2007. RESULTS: There were 618 (1%) women on methadone at delivery. Methadone-exposed women were more likely to be younger, to book late for antenatal care, and to be smokers. Methadone exposure was associated with an increased risk of very preterm birth <32 weeks of gestation (adjusted odds ratio [aOR], 2.47; 95% confidence interval [CI], 1.40-4.34), being small for gestational age <10th percentile (aOR, 3.27; 95% CI, 2.49-4.28), admission to the neonatal unit (aOR, 9.14; 95% CI, 7.21-11.57), and diagnosis of a major congenital anomaly (aOR, 1.94; 95% CI, 1.10-3.43). There was a dose-response relationship between methadone and neonatal abstinence syndrome. CONCLUSION: Methadone exposure is associated with an increased risk of adverse perinatal outcomes, even when known adverse sociodemographic factors have been accounted for. Methadone dose at delivery is 1 of the determinants of neonatal abstinence syndrome.
    Language
    eng
    ISSN
    1097-6868 (Electronic)
    0002-9378 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ajog.2010.10.004
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

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