Sweeten, soother and swaddle for retinopathy of prematurity screening: a randomised placebo controlled trial.
AffiliationDepartment of Paediatrics and Newborn Medicine, Coombe Women and Infants, University Hospital, Dublin, Ireland.
Analgesics/administration & dosage
Intensive Care, Neonatal/methods
Neonatal Screening/*adverse effects/methods
Pain/etiology/*prevention & control
Physical Examination/adverse effects/methods
Retinopathy of Prematurity/*diagnosis
Sucrose/administration & dosage
MetadataShow full item record
CitationArch Dis Child Fetal Neonatal Ed. 2010 Nov;95(6):F419-22. Epub 2010 Sep 28.
JournalArchives of disease in childhood. Fetal and neonatal edition
AbstractOBJECTIVE: To assess the efficacy of oral sucrose combined with swaddling and non-nutritive suck (NNS) as a method for reducing pain associated with retinopathy of prematurity (ROP) screening. DESIGN: Randomised placebo controlled study. SETTING: Tertiary level neonatal intensive care unit. SAMPLE: 40 infants undergoing primary eye examination for ROP screening. INTERVENTION: The control group were swaddled, and received 0.2 ml of sterile water given by mouth using a syringe and a soother. The intervention group were swaddled, and received 0.2 ml of sucrose 24% given by mouth using a syringe and a soother. RESULTS: 40 infants were included in the study. There was no difference in mean gestational age at birth, mean birth weight or corrected gestational age at first examination between both groups. The sucrose group had a significantly lower median Neonatal Pain, Agitation and Sedation Scale (N-PASS) score during ROP screening, initially following insertion of the speculum (6.5 vs 5, p=0.02) and subsequently during scleral indentation (9.5 vs 7.5, p=0.03). Fewer infants experienced episodes of desaturations or bradycardia in the intervention group (1 vs 4, p=0.18). CONCLUSION: ROP screening is a necessary but recognised painful procedure. Sucrose combined with NNS and swaddling reduced the behavioural and physiological pain responses. However, pain scores remained consistently high and appropriate pain relief for ROP screening remains a challenge.
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