• Login
    View Item 
    •   Home
    • Hospital Research
    • Leinster
    • Coombe Women & Infants University Hospital
    • View Item
    •   Home
    • Hospital Research
    • Leinster
    • Coombe Women & Infants University Hospital
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Map of Submissions

    Home Page
    UlsterN
    4708
    UlsterS
    4708
    Connacht
    1607
    Munster
    48
    Leinster
    426

    Browse

    All of Lenus, The Irish Health RepositoryCommunitiesTitleAuthorsDate publishedSubjectsThis CollectionTitleAuthorsDate publishedSubjects

    My Account

    LoginRegister

    About

    About LenusDirectory of Open Access JournalsOpen Access Publishing GuideNational Health Library & Knowledge ServiceGuide to Publishers' PoliciesFAQsTerms and ConditionsVision StatementRIAN Pathways to Irish ResearchHSE position statement on Open AccessNational Open Research Forum (NORF)Zenodo (European Open Research repository)

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    A randomised controlled trial of oxytocin 5IU and placebo infusion versus oxytocin 5IU and 30IU infusion for the control of blood loss at elective caesarean section--pilot study. ISRCTN 40302163.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    Publisher version
    View Source
    Access full-text PDFOpen Access
    View Source
    Check access options
    Check access options
    Authors
    Murphy, Deirdre J
    MacGregor, Honor
    Munishankar, Bhagya
    McLeod, Graeme
    Affiliation
    Academic Department of Obstetrics & Gynaecology, Coombe Women's Hospital &, Trinity College, University of Dublin, Dublin 8, Ireland. deirdre.j.murphy@tcd.ie
    Issue Date
    2012-02-01T10:56:55Z
    MeSH
    Adult
    Blood Loss, Surgical/*prevention & control
    Cesarean Section/*methods
    Female
    Humans
    Oxytocin/*administration & dosage
    Pilot Projects
    Placebos
    Postpartum Hemorrhage/*prevention & control
    Pregnancy
    Research Design
    Show allShow less
    
    Metadata
    Show full item record
    Citation
    Eur J Obstet Gynecol Reprod Biol. 2009 Jan;142(1):30-3. Epub 2008 Nov 5.
    Journal
    European journal of obstetrics, gynecology, and reproductive biology
    URI
    http://hdl.handle.net/10147/207989
    DOI
    10.1016/j.ejogrb.2008.09.004
    PubMed ID
    18977579
    Abstract
    OBJECTIVE: To compare the blood loss at elective lower segment caesarean section with administration of oxytocin 5IU bolus versus oxytocin 5IU bolus and oxytocin 30IU infusion and to establish whether a large multi-centre trial is feasible. STUDY DESIGN: Women booked for an elective caesarean section were recruited to a pilot randomised controlled trial and randomised to either oxytocin 5IU bolus and placebo infusion or oxytocin 5IU bolus and oxytocin 30IU infusion. We wished to establish whether the study design was feasible and acceptable and to establish sample size estimates for a definitive multi-centre trial. The outcome measures were total estimated blood loss at caesarean section and in the immediate postpartum period and the need for an additional uterotonic agent. RESULTS: A total of 115 women were randomised and 110 were suitable for analysis (5 protocol violations). Despite strict exclusion criteria 84% of the target population were considered eligible for study participation and of those approached only 15% declined to participate and 11% delivered prior to the planned date. The total mean estimated blood loss was lower in the oxytocin infusion arm compared to placebo (567 ml versus 624 ml) and fewer women had a major haemorrhage (>1000 ml, 14% versus 17%) or required an additional uterotonic agent (5% versus 11%). A sample size of 1500 in each arm would be required to demonstrate a 3% absolute reduction in major haemorrhage (from baseline 10%) with >80% power. CONCLUSION: An additional oxytocin infusion at elective caesarean section may reduce blood loss and warrants evaluation in a large multi-centre trial.
    Language
    eng
    ISSN
    1872-7654 (Electronic)
    0301-2115 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.ejogrb.2008.09.004
    Scopus Count
    Collections
    Coombe Women & Infants University Hospital

    entitlement

    Related articles

    • Study protocol. ECSSIT - Elective Caesarean Section Syntocinon Infusion Trial. A multi-centre randomised controlled trial of oxytocin (Syntocinon) 5 IU bolus and placebo infusion versus oxytocin 5 IU bolus and 40 IU infusion for the control of blood loss at elective caesarean section.
    • Authors: Murphy DJ, Carey M, Montgomery AA, Sheehan SR, ECSSIT Study Group.
    • Issue date: 2009 Aug 24
    • Use of additional oxytocin to reduce blood loss at elective caesarean section: A randomised control trial.
    • Authors: Güngördük K, Asicioglu O, Celikkol O, Olgac Y, Ark C
    • Issue date: 2010 Feb
    • Oxytocin bolus versus oxytocin bolus and infusion for control of blood loss at elective caesarean section: double blind, placebo controlled, randomised trial.
    • Authors: Sheehan SR, Montgomery AA, Carey M, McAuliffe FM, Eogan M, Gleeson R, Geary M, Murphy DJ, ECSSIT Study Group.
    • Issue date: 2011 Aug 1
    • Utilization of carbetocin for prevention of postpartum hemorrhage after cesarean section: a randomized clinical trial.
    • Authors: Borruto F, Treisser A, Comparetto C
    • Issue date: 2009 Nov
    • Oxytocin-ergometrine co-administration does not reduce blood loss at caesarean delivery for labour arrest.
    • Authors: Balki M, Dhumne S, Kasodekar S, Kingdom J, Windrim R, Carvalho JC
    • Issue date: 2008 Apr
    National Health Library & Knowledge Service | Health Service Executive | Dr Steevens' Hospital | Dublin 8 | Ireland
    lenus@hse.ie | Tel +353 (1) 6352558
    DSpace software copyright © 2002-2017  DuraSpace
    Contact Us | Disclaimer
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.