AuthorsConnell, Paul P
Keane, Pearse A
O'Neill, Evelyn C
Altaie, Rasha W
Nolan, John M
AffiliationWaterford Regional Hospital, Dunmore Road, Waterford, Ireland.
MetadataShow full item record
CitationJ Ophthalmol. 2009;2009:360764. Epub 2009 Sep 6.
JournalJournal of ophthalmology
AbstractAge-related maculopathy (ARM) is the leading cause of blindness in the elderly. Although beneficial therapeutic strategies have recently begun to emerge, much remains unclear regarding the etiopathogenesis of this disorder. Epidemiologic studies have enhanced our understanding of ARM, but the data, often conflicting, has led to difficulties with drawing firm conclusions with respect to risk for this condition. As a consequence, we saw a need to assimilate the published findings with respect to risk factors for ARM, through a review of the literature appraising results from published cross-sectional studies, prospective cohort studies, case series, and case control studies investigating risk for this condition. Our review shows that, to date, and across a spectrum of epidemiologic study designs, only age, cigarette smoking, and family history of ARM have been consistently demonstrated to represent risk for this condition. In addition, genetic studies have recently implicated many genes in the pathogenesis of age-related maculopathy, including Complement Factor H, PLEKHA 1, and LOC387715/HTRA1, demonstrating that environmental and genetic factors are important for the development of ARM suggesting that gene-environment interaction plays an important role in the pathogenesis of this condition.
- CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to age-related maculopathy: AREDS and CHS cohorts and meta-analyses.
- Authors: Conley YP, Jakobsdottir J, Mah T, Weeks DE, Klein R, Kuller L, Ferrell RE, Gorin MB
- Issue date: 2006 Nov 1
- Routine eye examinations for persons 20-64 years of age: an evidence-based analysis.
- Authors: Medical Advisory Secretariat.
- Issue date: 2006
- C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.
- Authors: Jakobsdottir J, Conley YP, Weeks DE, Ferrell RE, Gorin MB
- Issue date: 2008 May 21
- Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking.
- Authors: Hughes AE, Orr N, Patterson C, Esfandiary H, Hogg R, McConnell V, Silvestri G, Chakravarthy U
- Issue date: 2007 Dec
- A clinician's view of the molecular genetics of age-related maculopathy.
- Authors: Gorin MB
- Issue date: 2007 Jan