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    Risk factors for age-related maculopathy.

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    Authors
    Connell, Paul P
    Keane, Pearse A
    O'Neill, Evelyn C
    Altaie, Rasha W
    Loane, Edward
    Neelam, Kumari
    Nolan, John M
    Beatty, Stephen
    Affiliation
    Waterford Regional Hospital, Dunmore Road, Waterford, Ireland.
    Issue Date
    2012-02-01T10:52:34Z
    
    Metadata
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    Citation
    J Ophthalmol. 2009;2009:360764. Epub 2009 Sep 6.
    Journal
    Journal of ophthalmology
    URI
    http://hdl.handle.net/10147/207958
    DOI
    10.1155/2009/360764
    PubMed ID
    20339564
    Abstract
    Age-related maculopathy (ARM) is the leading cause of blindness in the elderly. Although beneficial therapeutic strategies have recently begun to emerge, much remains unclear regarding the etiopathogenesis of this disorder. Epidemiologic studies have enhanced our understanding of ARM, but the data, often conflicting, has led to difficulties with drawing firm conclusions with respect to risk for this condition. As a consequence, we saw a need to assimilate the published findings with respect to risk factors for ARM, through a review of the literature appraising results from published cross-sectional studies, prospective cohort studies, case series, and case control studies investigating risk for this condition. Our review shows that, to date, and across a spectrum of epidemiologic study designs, only age, cigarette smoking, and family history of ARM have been consistently demonstrated to represent risk for this condition. In addition, genetic studies have recently implicated many genes in the pathogenesis of age-related maculopathy, including Complement Factor H, PLEKHA 1, and LOC387715/HTRA1, demonstrating that environmental and genetic factors are important for the development of ARM suggesting that gene-environment interaction plays an important role in the pathogenesis of this condition.
    Language
    eng
    ISSN
    2090-0058 (Electronic)
    2090-004X (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1155/2009/360764
    Scopus Count
    Collections
    University Hospital Waterford

    entitlement

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