Brain activation predicts treatment improvement in patients with major depressive disorder.
AuthorsSamson, Andrea C
AffiliationDepartment of Psychiatry, School of Medicine & Trinity College Institute of, Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital, incorporating the National Children's Hospital (AMNCH), & St. James's Hospital,, Trinity College, Dublin, Ireland. firstname.lastname@example.org
Analysis of Variance
Antidepressive Agents/pharmacology/therapeutic use
Brain/blood supply/drug effects/*physiopathology
Depressive Disorder, Major/drug therapy/*pathology
Image Processing, Computer-Assisted
Magnetic Resonance Imaging/methods
Pattern Recognition, Visual/drug effects
Predictive Value of Tests
Reaction Time/drug effects/physiology
MetadataShow full item record
CitationJ Psychiatr Res. 2011 Sep;45(9):1214-22. Epub 2011 Apr 7.
JournalJournal of psychiatric research
AbstractMajor depressive disorder (MDD) is associated with alterations in brain function that might be useful for therapy evaluation. The current study aimed to identify predictors for therapy improvement and to track functional brain changes during therapy. Twenty-one drug-free patients with MDD underwent functional MRI twice during performance of an emotional perception task: once before and once after 4 weeks of antidepressant treatment (mirtazapine or venlafaxine). Twelve healthy controls were investigated once with the same methods. A significant difference between groups was a relative greater activation of the right dorsolateral prefrontal cortex (dlPFC) in the patients vs. controls. Before treatment, patients responding better to pharmacological treatment showed greater activation in the dorsomedial PFC (dmPFC), posterior cingulate cortex (pCC) and superior frontal gyrus (SFG) when viewing of negative emotional pictures was compared with the resting condition. Activations in the caudate nucleus and insula contrasted for emotional compared to neutral stimuli were also associated with successful treatment. Responders had also significantly higher levels of activation, compared to non-responders, in a range of other brain regions. Brain activation related to treatment success might be related to altered self-referential processes and a differential response to external emotional stimuli, suggesting differences in the processing of emotionally salient stimuli between those who are likely to respond to pharmacological treatment and those who will not. The present investigation suggests the pCC, dmPFC, SFG, caudate nucleus and insula may have a key role as a biological marker for treatment response and predictor for therapeutic success.
- Altered inhibition of negative emotions in subjects at family risk of major depressive disorder.
- Authors: Lisiecka DM, Carballedo A, Fagan AJ, Connolly G, Meaney J, Frodl T
- Issue date: 2012 Feb
- Emotionally negative stimuli can overcome attentional deficits in patients with visuo-spatial hemineglect.
- Authors: Grabowska A, Marchewka A, Seniów J, Polanowska K, Jednoróg K, Królicki L, Kossut M, Członkowska A
- Issue date: 2011 Oct
- Altered neural response of the appetitive emotional system in cocaine addiction: an fMRI Study.
- Authors: Asensio S, Romero MJ, Palau C, Sanchez A, Senabre I, Morales JL, Carcelen R, Romero FJ
- Issue date: 2010 Oct
- Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder.
- Authors: Lee BT, Seok JH, Lee BC, Cho SW, Yoon BJ, Lee KU, Chae JH, Choi IG, Ham BJ
- Issue date: 2008 Apr 1
- Structural and cognitive deficits in remitting and non-remitting recurrent depression: a voxel-based morphometric study.
- Authors: Li CT, Lin CP, Chou KH, Chen IY, Hsieh JC, Wu CL, Lin WC, Su TP
- Issue date: 2010 Mar