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    Brain activation predicts treatment improvement in patients with major depressive disorder.

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    Authors
    Samson, Andrea C
    Meisenzahl, Eva
    Scheuerecker, Johanna
    Rose, Emma
    Schoepf, Veronika
    Wiesmann, Martin
    Frodl, Thomas
    Affiliation
    Department of Psychiatry, School of Medicine & Trinity College Institute of, Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital, incorporating the National Children's Hospital (AMNCH), & St. James's Hospital,, Trinity College, Dublin, Ireland. andrea.samson@stanford.edu
    Issue Date
    2012-02-01T10:50:37Z
    MeSH
    Adult
    Analysis of Variance
    Antidepressive Agents/pharmacology/therapeutic use
    Brain/blood supply/drug effects/*physiopathology
    *Brain Mapping
    Depressive Disorder, Major/drug therapy/*pathology
    Emotions/drug effects/*physiology
    Female
    Humans
    Image Processing, Computer-Assisted
    Magnetic Resonance Imaging/methods
    Male
    Middle Aged
    Neuropsychological Tests
    Oxygen/blood
    Pattern Recognition, Visual/drug effects
    Photic Stimulation/methods
    Predictive Value of Tests
    Reaction Time/drug effects/physiology
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    Citation
    J Psychiatr Res. 2011 Sep;45(9):1214-22. Epub 2011 Apr 7.
    Journal
    Journal of psychiatric research
    URI
    http://hdl.handle.net/10147/207937
    DOI
    10.1016/j.jpsychires.2011.03.009
    PubMed ID
    21477817
    Abstract
    Major depressive disorder (MDD) is associated with alterations in brain function that might be useful for therapy evaluation. The current study aimed to identify predictors for therapy improvement and to track functional brain changes during therapy. Twenty-one drug-free patients with MDD underwent functional MRI twice during performance of an emotional perception task: once before and once after 4 weeks of antidepressant treatment (mirtazapine or venlafaxine). Twelve healthy controls were investigated once with the same methods. A significant difference between groups was a relative greater activation of the right dorsolateral prefrontal cortex (dlPFC) in the patients vs. controls. Before treatment, patients responding better to pharmacological treatment showed greater activation in the dorsomedial PFC (dmPFC), posterior cingulate cortex (pCC) and superior frontal gyrus (SFG) when viewing of negative emotional pictures was compared with the resting condition. Activations in the caudate nucleus and insula contrasted for emotional compared to neutral stimuli were also associated with successful treatment. Responders had also significantly higher levels of activation, compared to non-responders, in a range of other brain regions. Brain activation related to treatment success might be related to altered self-referential processes and a differential response to external emotional stimuli, suggesting differences in the processing of emotionally salient stimuli between those who are likely to respond to pharmacological treatment and those who will not. The present investigation suggests the pCC, dmPFC, SFG, caudate nucleus and insula may have a key role as a biological marker for treatment response and predictor for therapeutic success.
    Language
    eng
    ISSN
    1879-1379 (Electronic)
    0022-3956 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.jpsychires.2011.03.009
    Scopus Count
    Collections
    Tallaght University Hospital

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