Homocysteine status and cardiovascular risk factors in patients with psoriasis: a case-control study.
AffiliationDepartment of Dermatology, Adelaide and Meath Hospital incorporating National, Children's Hospital, Tallaght, Dublin, Ireland.
Severity of Illness Index
Vitamin B 12/*blood
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CitationClin Exp Dermatol. 2011 Jan;36(1):19-23. doi: 10.1111/j.1365-2230.2010.03877.x.
JournalClinical and experimental dermatology
AbstractBACKGROUND: Psoriasis is a hyperproliferative, cutaneous disorder with the potential to lower levels of folate. This may result in raised levels of homocysteine, an independent risk factor for the development of cardiovascular disease. OBJECTIVE: A study was conducted to compare levels of red-cell folate (RCF) and homocysteine in patients with psoriasis and in healthy controls. Levels of homocysteine were also examined in the context of other major cardiovascular risk factors. METHODS: In total, 20 patients with psoriasis and 20 controls had their RCF, homo-cysteine and other conventional cardiovascular risk factors assessed. RESULTS: Patients with psoriasis had a trend towards lower levels of RCF. Significantly raised levels of homocysteine were found in patients with psoriasis compared with controls (P = 0.007). There was no correlation between homocysteine levels, RCF levels or disease activity as measured by the Psoriasis Area and Severity Index. Patients with psoriasis had higher body mass index (P < 0.004) and higher systolic blood pressure (P < 0.001) than controls. This may contribute to the excess cardiovascular mortality observed in patients with psoriasis.