Affiliation
Department of Gastroenterology, Adelaide and Meath Hospital incorporating the, National Children's Hospital Tallaght, Trinity College Dublin, Dublin, Ireland.Issue Date
2012-02-01T10:50:06ZMeSH
Anti-Bacterial Agents/*therapeutic useClinical Trials as Topic
Drug Resistance, Bacterial
Helicobacter Infections/*drug therapy
Helicobacter pylori/*drug effects/physiology
Humans
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Helicobacter. 2009 Sep;14 Suppl 1:46-51.Journal
HelicobacterDOI
10.1111/j.1523-5378.2009.00704.xPubMed ID
19712168Abstract
This article aims to examine current best practice in the field reference to first-line, second-line, rescue and emerging treatment regimens for Helicobacter pylori eradication. The recommended first-line treatment in published guidelines in Europe and North American is proton pump inhibitor combined with amoxicillin and clarithromycin being the favoured regimen. Rates of eradication with this regimen however are falling alarmingly due to a combination of antibiotic resistance and poor compliance with therapy. Bismuth based quadruple therapies and levofloxacin based regimes have been shown to be effective second line regimens. Third-line options include regimes based on rifabutin or furazolidone, but susceptibility testing is the most rational option here, but is currently not used widely enough. Sequential therapy is promising but needs further study and validation outside of Italy. Although the success of first line treatments is falling, if compliance is good and a clear treatment paradigm adhered to, almost universal eradication rates can still be achieved. If compliance is not achievable, the problem of antibiotic resistance will continue to beset any combination of drugs used for H. pylori eradication.Language
engISSN
1523-5378 (Electronic)1083-4389 (Linking)
ae974a485f413a2113503eed53cd6c53
10.1111/j.1523-5378.2009.00704.x
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