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    Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology.

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    Authors
    Whitty, Peter F
    Owoeye, Olabisi
    Waddington, John L
    Affiliation
    Department of Psychiatry, The Adelaide and Meath Hospital, Tallaght, Dublin,, Ireland.
    Issue Date
    2012-02-01T10:49:59Z
    MeSH
    Adult
    Antipsychotic Agents/adverse effects
    Biological Markers
    Brain/*physiopathology
    Central Nervous System Diseases/chemically induced/*physiopathology
    Cognition Disorders/physiopathology
    Dyskinesias/*physiopathology
    Humans
    Neural Pathways/physiopathology
    Schizophrenia/drug therapy/*physiopathology
    Schizophrenic Psychology
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    Citation
    Schizophr Bull. 2009 Mar;35(2):415-24. Epub 2008 Sep 12.
    Journal
    Schizophrenia bulletin
    URI
    http://hdl.handle.net/10147/207915
    DOI
    10.1093/schbul/sbn126
    PubMed ID
    18791074
    Abstract
    While it has long been considered whether the pathobiology of schizophrenia extends beyond its defining symptoms to involve diverse domains of abnormality, in the manner of a systemic disease, studies of neuromotor dysfunction have been confounded by treatment with antipsychotic drugs. This challenge has been illuminated by a new generation of studies on first-episode schizophrenia before initiation of antipsychotic treatment and by opportunities in developing countries to study chronically ill patients who have remained antipsychotic naive due to limitations in provision of psychiatric care. Building from studies in antipsychotic-naive patients, this article reviews 2 domains of neuromotor dysfunction in schizophrenia: neurological signs and involuntary movements. The presence and characteristics of neurological signs in untreated vis-a-vis treated psychosis indicate a vulnerability marker for schizophrenia and implicate disruption to neuronal circuits linking the basal ganglia, cerebral cortex, and cerebellum. The presence and characteristics of involuntary movements in untreated vis-a-vis treated psychosis indicate an intrinsic feature of the disease process and implicate dysfunction in cortical-basal ganglia-cortical circuitry. These neuromotor disorders of schizophrenia join other markers of subtle but pervasive cerebral and extracerebral, systemic dysfunction, and complement current concepts of schizophrenia as a disorder of developmentally determined cortical-basal ganglia-thalamo-cortical/cerebellar network disconnectivity.
    Language
    eng
    ISSN
    0586-7614 (Print)
    0586-7614 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1093/schbul/sbn126
    Scopus Count
    Collections
    Tallaght University Hospital

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