Neurological signs and involuntary movements in schizophrenia: intrinsic to and informative on systems pathobiology.
AffiliationDepartment of Psychiatry, The Adelaide and Meath Hospital, Tallaght, Dublin,, Ireland.
Antipsychotic Agents/adverse effects
Central Nervous System Diseases/chemically induced/*physiopathology
MetadataShow full item record
CitationSchizophr Bull. 2009 Mar;35(2):415-24. Epub 2008 Sep 12.
AbstractWhile it has long been considered whether the pathobiology of schizophrenia extends beyond its defining symptoms to involve diverse domains of abnormality, in the manner of a systemic disease, studies of neuromotor dysfunction have been confounded by treatment with antipsychotic drugs. This challenge has been illuminated by a new generation of studies on first-episode schizophrenia before initiation of antipsychotic treatment and by opportunities in developing countries to study chronically ill patients who have remained antipsychotic naive due to limitations in provision of psychiatric care. Building from studies in antipsychotic-naive patients, this article reviews 2 domains of neuromotor dysfunction in schizophrenia: neurological signs and involuntary movements. The presence and characteristics of neurological signs in untreated vis-a-vis treated psychosis indicate a vulnerability marker for schizophrenia and implicate disruption to neuronal circuits linking the basal ganglia, cerebral cortex, and cerebellum. The presence and characteristics of involuntary movements in untreated vis-a-vis treated psychosis indicate an intrinsic feature of the disease process and implicate dysfunction in cortical-basal ganglia-cortical circuitry. These neuromotor disorders of schizophrenia join other markers of subtle but pervasive cerebral and extracerebral, systemic dysfunction, and complement current concepts of schizophrenia as a disorder of developmentally determined cortical-basal ganglia-thalamo-cortical/cerebellar network disconnectivity.
- Modelling the neuromotor abnormalities of psychotic illness: Putative mechanisms and systems dysfunction.
- Authors: Waddington JL, O'Tuathaigh CM
- Issue date: 2018 Oct
- Relationship of neuromotor disturbances to psychosis symptoms in first-episode neuroleptic-naive schizophrenia patients.
- Authors: Cortese L, Caligiuri MP, Malla AK, Manchanda R, Takhar J, Haricharan R
- Issue date: 2005 Jun 1
- Neurological soft signs in schizophrenia spectrum disorders are not confounded by current antipsychotic dosage.
- Authors: Fritze S, Sambataro F, Kubera KM, Bertolino AL, Topor CE, Wolf RC, Hirjak D
- Issue date: 2020 Feb
- Neuromotor dysfunction in early psychosis.
- Authors: Whitehorn D, Kopala LC
- Issue date: 2002 Jun
- Cognitive dysfunction, negative symptoms, and tardive dyskinesia in schizophrenia. Their association in relation to topography of involuntary movements and criterion of their abnormality.
- Authors: Waddington JL, Youssef HA, Dolphin C, Kinsella A
- Issue date: 1987 Oct