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    Neural correlates of treatment outcome in major depression.

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    Authors
    Lisiecka, Danuta
    Meisenzahl, Eva
    Scheuerecker, Johanna
    Schoepf, Veronica
    Whitty, Peter
    Chaney, Aisling
    Moeller, Hans-Juergen
    Wiesmann, Martin
    Frodl, Thomas
    Affiliation
    Department of Psychiatry, School of Medicine & Trinity College Institute of, Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital (AMiNCH), & St James's Hospital,, Trinity College, Dublin, Ireland.
    Issue Date
    2012-02-01T10:49:52Z
    MeSH
    Adult
    Affect/*drug effects
    Antidepressive Agents/administration & dosage/*therapeutic use
    Biological Markers/analysis
    Cerebral Cortex/physiopathology
    Cyclohexanols/administration & dosage/*therapeutic use
    Depressive Disorder, Major/*drug therapy/physiopathology/psychology
    Face
    Female
    Frontal Lobe/*physiopathology
    Humans
    Male
    Mianserin/administration & dosage/*analogs & derivatives/therapeutic use
    Middle Aged
    Nerve Net/*drug effects/physiopathology
    Psychiatric Status Rating Scales
    Treatment Outcome
    Young Adult
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    Citation
    Int J Neuropsychopharmacol. 2011 May;14(4):521-34. Epub 2010 Dec 23.
    Journal
    The international journal of neuropsychopharmacology / official scientific, journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
    URI
    http://hdl.handle.net/10147/207911
    DOI
    10.1017/S1461145710001513
    PubMed ID
    21205435
    Abstract
    There is a need to identify clinically useful biomarkers in major depressive disorder (MDD). In this context the functional connectivity of the orbitofrontal cortex (OFC) to other areas of the affect regulation circuit is of interest. The aim of this study was to identify neural changes during antidepressant treatment and correlates associated with the treatment outcome. In an exploratory analysis it was investigated whether functional connectivity measures moderated a response to mirtazapine and venlafaxine. Twenty-three drug-free patients with MDD were recruited from the Department of Psychiatry and Psychotherapy of the Ludwig-Maximilians University in Munich. The patients were subjected to a 4-wk randomized clinical trial with two common antidepressants, venlafaxine or mirtazapine. Functional connectivity of the OFC, derived from functional magnetic resonance imaging with an emotional face-matching task, was measured before and after the trial. Higher OFC connectivity with the left motor areas and the OFC regions prior to the trial characterized responders (p<0.05, false discovery rate). The treatment non-responders were characterized by higher OFC-cerebellum connectivity. The strength of response was positively correlated with functional coupling between left OFC and the caudate nuclei and thalami. Differences in longitudinal changes were detected between venlafaxine and mirtazapine treatment in the motor areas, cerebellum, cingulate gyrus and angular gyrus. These results indicate that OFC functional connectivity might be useful as a marker for therapy response to mirtazapine and venlafaxine and to reconstruct the differences in their mechanism of action.
    Language
    eng
    ISSN
    1469-5111 (Electronic)
    1461-1457 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1017/S1461145710001513
    Scopus Count
    Collections
    Tallaght University Hospital

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