AffiliationDepartment of Psychiatry, School of Medicine & Trinity College Institute of, Neuroscience, Integrated Neuroimaging, The Adelaide and Meath Hospital, Incorporating the National Children's Hospital (AMiNCH), & St James's Hospital,, Trinity College, Dublin, Ireland.
Antidepressive Agents/administration & dosage/*therapeutic use
Cyclohexanols/administration & dosage/*therapeutic use
Depressive Disorder, Major/*drug therapy/physiopathology/psychology
Mianserin/administration & dosage/*analogs & derivatives/therapeutic use
Nerve Net/*drug effects/physiopathology
Psychiatric Status Rating Scales
MetadataShow full item record
CitationInt J Neuropsychopharmacol. 2011 May;14(4):521-34. Epub 2010 Dec 23.
JournalThe international journal of neuropsychopharmacology / official scientific, journal of the Collegium Internationale Neuropsychopharmacologicum (CINP)
AbstractThere is a need to identify clinically useful biomarkers in major depressive disorder (MDD). In this context the functional connectivity of the orbitofrontal cortex (OFC) to other areas of the affect regulation circuit is of interest. The aim of this study was to identify neural changes during antidepressant treatment and correlates associated with the treatment outcome. In an exploratory analysis it was investigated whether functional connectivity measures moderated a response to mirtazapine and venlafaxine. Twenty-three drug-free patients with MDD were recruited from the Department of Psychiatry and Psychotherapy of the Ludwig-Maximilians University in Munich. The patients were subjected to a 4-wk randomized clinical trial with two common antidepressants, venlafaxine or mirtazapine. Functional connectivity of the OFC, derived from functional magnetic resonance imaging with an emotional face-matching task, was measured before and after the trial. Higher OFC connectivity with the left motor areas and the OFC regions prior to the trial characterized responders (p<0.05, false discovery rate). The treatment non-responders were characterized by higher OFC-cerebellum connectivity. The strength of response was positively correlated with functional coupling between left OFC and the caudate nuclei and thalami. Differences in longitudinal changes were detected between venlafaxine and mirtazapine treatment in the motor areas, cerebellum, cingulate gyrus and angular gyrus. These results indicate that OFC functional connectivity might be useful as a marker for therapy response to mirtazapine and venlafaxine and to reconstruct the differences in their mechanism of action.
- Tranylcypromine versus venlafaxine plus mirtazapine following three failed antidepressant medication trials for depression: a STAR*D report.
- Authors: McGrath PJ, Stewart JW, Fava M, Trivedi MH, Wisniewski SR, Nierenberg AA, Thase ME, Davis L, Biggs MM, Shores-Wilson K, Luther JF, Niederehe G, Warden D, Rush AJ
- Issue date: 2006 Sep
- Mirtazapine orally disintegrating tablets versus venlafaxine extended release: a double-blind, randomized multicenter trial comparing the onset of antidepressant response in patients with major depressive disorder.
- Authors: Benkert O, Szegedi A, Philipp M, Kohnen R, Heinrich C, Heukels A, van der Vegte-Senden M, Baker RA, Simmons JH, Schutte AJ
- Issue date: 2006 Feb
- The neural substrates of affective processing in depressed patients treated with venlafaxine.
- Authors: Davidson RJ, Irwin W, Anderle MJ, Kalin NH
- Issue date: 2003 Jan
- Heart rate variability during antidepressant treatment with venlafaxine and mirtazapine.
- Authors: Terhardt J, Lederbogen F, Feuerhack A, Hamann-Weber B, Gilles M, Schilling C, Lecei O, Deuschle M
- Issue date: 2013 Nov-Dec
- Comparisons of the efficacy and tolerability of extended-release venlafaxine, mirtazapine, and paroxetine in treatment-resistant depression: a double-blind, randomized pilot study in a Chinese population.
- Authors: Fang Y, Yuan C, Xu Y, Chen J, Wu Z, Cao L, Yi Z, Hong W, Wang Y, Jiang K, Gao K, Cui X, Nierenberg AA, OPERATION Study Team.
- Issue date: 2010 Aug