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    Do we really understand the role of the oesophagogastric junction in disease?

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    Authors
    McMahon, Barry P
    Jobe, Blair A
    Pandolfino, John E
    Gregersen, Hans
    Affiliation
    Department of Medical Physics and Clinical Engineering, Adelaide and Meath, Hospital, Tallaght, Dublin 24, Ireland. barry.mcmahon@tcd.ie
    Issue Date
    2012-02-01T10:49:39Z
    MeSH
    Diagnostic Techniques, Digestive System
    Electric Impedance
    Esophageal Achalasia/diagnosis/*etiology/physiopathology
    Esophagogastric Junction/*physiopathology
    Gastroesophageal Reflux/diagnosis/*etiology/physiopathology
    Humans
    Manometry
    
    Metadata
    Show full item record
    Citation
    World J Gastroenterol. 2009 Jan 14;15(2):144-50.
    Journal
    World journal of gastroenterology : WJG
    URI
    http://hdl.handle.net/10147/207904
    PubMed ID
    19132763
    Abstract
    The role of the oesophago-gastric junction (OGJ) in gastro-oesophageal reflux disease is still not completely understood, and there is no clinically used method to assess the OGJ function in patients. Only indirect methods such as pH studies are carried out. The OGJ acts a valve controlling the flow of solids, liquids and gases between the oesophagus and the stomach. Manometry can determine if a sphincter is toned or relaxed; but, it cannot confirm that the sphincter region is actually open. Distension is a new technique for measuring function in the OGJ. By measuring the cross-sectional area through the narrow region in the junction during distension of a catheter mounted bag, much more information on the opening and closing patterns of the junction can be determined. This technique has already been demonstrated to show changes in the OGJ after surgical treatments for reflux disease. New measurement ideas around the concept of distending the OGJ offer new hope that a clinically useable test for compliance at the junction can be developed and could potentially help in determining appropriate therapy.
    Language
    eng
    ISSN
    1007-9327 (Print)
    1007-9327 (Linking)
    Collections
    Tallaght University Hospital

    entitlement

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