Efficacy of triamcinolone acetonide and bupivacaine for pain after lumbar discectomy.
AffiliationDepartment of Trauma and Reconstructive Surgery, Adelaide and Meath Hospital, incorporating the National Children Hospital, Tallaght, Dublin 24, Republic of, Ireland. email@example.com
Anesthetics, Local/therapeutic use
Anti-Inflammatory Agents/therapeutic use
Drug Therapy, Combination
Pain Measurement/*drug effects
Pain, Postoperative/*drug therapy
Triamcinolone Acetonide/*therapeutic use
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CitationEur Spine J. 2010 Jul;19(7):1099-103. Epub 2010 Mar 12.
JournalEuropean spine journal : official publication of the European Spine Society, the , European Spinal Deformity Society, and the European Section of the Cervical Spine, Research Society
AbstractThe study is a prospective blinded randomised controlled trial to compare the efficacy of triamcinolone acetonide, bupivacaine or in combination in managing pain after lumbar discectomy. Patients undergoing primary single-level lumbar discectomy were randomised. Triamcinolone acetonide, bupivacaine or in combination was instilled at the nerve root as decompression. Preoperative, day 1 and 6 weeks pain score, 24-h postoperative opiate requirements and duration of inpatient stay were recorded. Data was analysed using Mann-Whitney test for statistical significance. 100 patients were recruited. A significant difference was noted in day one postoperative mean pain score, mean 24-h opiate requirement and mean inpatient stay in the triamcinolone acetonide and bupivacaine group. At 8 weeks postoperatively, no significant differences were seen in the pain score in all groups. Significant postoperative pain reduction and opiate requirements in the first 24 h, and significantly shortened duration of inpatient stay were achieved in the triamcinolone acetonide and bupivacaine group compared with other groups.