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    Variation in the vitamin D receptor gene is not associated with risk of colorectal cancer in the Czech Republic.

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    Authors
    Hughes, David J
    Hlavata, Ivona
    Soucek, Pavel
    Pardini, Barbara
    Naccarati, Alessio
    Vodickova, Ludmila
    Jenab, Mazda
    Vodicka, Pavel
    Affiliation
    Department of Clinical Medicine, Trinity College Centre for Health Sciences,, Adelaide and Meath Hospital, Dublin 24, Ireland. hughesd4@tcd.ie
    Issue Date
    2012-02-01T10:49:22Z
    MeSH
    Adult
    Aged
    Aged, 80 and over
    Case-Control Studies
    Colon/metabolism
    Colorectal Neoplasms/*genetics
    Czech Republic
    DNA/genetics
    Female
    Humans
    Male
    Middle Aged
    Polymerase Chain Reaction
    Polymorphism, Genetic/*genetics
    Prognosis
    Receptors, Calcitriol/*genetics
    Rectum/metabolism
    Risk Factors
    Vitamin D/metabolism
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    Citation
    J Gastrointest Cancer. 2011 Sep;42(3):149-54.
    Journal
    Journal of gastrointestinal cancer
    URI
    http://hdl.handle.net/10147/207894
    DOI
    10.1007/s12029-010-9168-6
    PubMed ID
    20585998
    Abstract
    PURPOSE: Increased levels of vitamin D may protect against colorectal cancer (CRC) development and recurrence. Accumulating epidemiologic evidence suggests these effects may be partly mediated by genetic variants of the vitamin D receptor (VDR) proposed to be associated with altered risk of CRC. We wished to determine if common VDR polymorphisms affected CRC risk in the Czech Republic, a homogenous European population with a high CRC incidence rate. METHODS: Frequencies of the common VDR gene polymorphisms rs2238136, rs1544410 (BsmI), rs7975232 (ApaI), and rs731236 (TaqI) were determined using allele-specific PCR in a case control analysis of a series of 754 CRC patients and 627 patients without malignant disease recruited from centers throughout the Czech Republic. Unconditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the association between these variants and risk of CRC. RESULTS: None of the four polymorphisms tested had any significant effect on CRC risk. No significant differences were observed in susceptibility when the population was stratified by anatomical sub-site, sex, BMI, smoking, alcohol, or presence of polyps. CONCLUSIONS: We conclude that common variation in the VDR gene had little effect on its own on predisposition to sporadic CRC in the Czech population.
    Language
    eng
    ISSN
    1941-6636 (Electronic)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s12029-010-9168-6
    Scopus Count
    Collections
    Tallaght University Hospital

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