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    Hematological abnormalities in adult patients with Down's syndrome.

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    Authors
    McLean, S
    McHale, C
    Enright, H
    Affiliation
    Department of Haematology, Adelaide and Meath Hospital, Dublin, Incorporating the, National Children's Hospital, Tallaght, D24, Dublin, Ireland. Smclean81@yahoo.com
    Issue Date
    2012-02-01T10:49:19Z
    MeSH
    Adult
    Down Syndrome/complications/epidemiology/*physiopathology
    Female
    Humans
    Ireland/epidemiology
    Male
    Middle Aged
    Myelodysplastic Syndromes/epidemiology/etiology/*physiopathology
    Retrospective Studies
    
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    Citation
    Ir J Med Sci. 2009 Mar;178(1):35-8. Epub 2008 Nov 20.
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/207892
    DOI
    10.1007/s11845-008-0223-2
    PubMed ID
    19020924
    Abstract
    BACKGROUND: There is a paucity of data regarding hematological abnormalities in adults with Down's syndrome (DS). AIMS: We aimed to characterize hematological abnormalities in adult patients with DS and determine their long-term significance. METHODS: We retrospectively studied a cohort of nine DS patients referred to the adult hematology service in our institution between May 2001 and April 2008. Data collected were: full blood count (FBC), comorbidities, investigations performed, duration of follow-up and outcome to most recent follow-up. RESULTS: Median follow-up was 26 months (9-71). Of the nine patients, two had myelodysplastic syndrome (MDS) at presentation. Of these, one progressed, with increasing marrow failure, and requiring support with transfusions and gCSF. The remaining eight patients, with a variety of hematological abnormalities including leukopenia, macrocytosis, and thrombocytopenia, had persistently abnormal FBCs. However there was no evidence of progression, and no patient has evolved to acute myeloid leukemia (AML). CONCLUSIONS: MDS is a complication of DS and may require supportive therapy. However, minor hematological abnormalities are common in adult DS patients, and may not signify underlying marrow disease.
    Language
    eng
    ISSN
    1863-4362 (Electronic)
    0021-1265 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-008-0223-2
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