Lipoprotein subclass patterns in women with polycystic ovary syndrome (PCOS) compared with equally insulin-resistant women without PCOS.
Affiliation
Department of Endocrinology and Diabetes, Adelaide and Meath Hospital, and School, of Public Health and Population Science, University College Dublin, Dublin 24,, Ireland.Issue Date
2012-02-01T10:49:17ZMeSH
AdultBody Mass Index
Case-Control Studies
Chi-Square Distribution
Cholesterol/blood
Electrophoresis, Polyacrylamide Gel
Female
Glucose Tolerance Test
Humans
Immunoassay
Insulin/blood
Insulin Resistance/*physiology
Lipoproteins/*blood/classification
Polycystic Ovary Syndrome/*blood
Regression Analysis
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J Clin Endocrinol Metab. 2010 Aug;95(8):3933-9. Epub 2010 Jun 2.Journal
The Journal of clinical endocrinology and metabolismDOI
10.1210/jc.2009-2444PubMed ID
20519354Abstract
OBJECTIVES: Women with polycystic ovary syndrome (PCOS) are more insulin resistant and display an atherogenic lipid profile compared with normal women of similar body mass index (BMI). Insulin resistance (IR) at least partially underlies the dyslipidemia of PCOS, but it is unclear whether PCOS status per se confers additional risk. RESEARCH DESIGN AND METHODS: Using a case-control design, we compared plasma lipids and lipoprotein subclasses (using polyacrylamide gel tube electrophoresis) in 70 women with PCOS (National Institutes of Health criteria) and 70 normal women pair matched for age, BMI, and IR (homeostasis model assessment-IR, quantitative insulin sensitivity check index, and the Avignon Index). Subjects were identified as having a (less atherogenic) type A pattern consisting predominantly of large low-density lipoprotein (LDL) subfractions or a (more atherogenic) non-A pattern consisting predominantly of small-dense LDL subfractions. RESULTS: Total, high-density lipoprotein, or LDL cholesterol, or triacylglycerol did not differ between the groups, but very low-density lipoprotein levels (P<0.05) were greater in women with PCOS, whereas a non-A LDL profile was seen in 12.9% compared with 2.9% of controls (P<0.05, chi2). Multiple regression analysis revealed homeostasis model assessment-IR and waist circumference to be independent predictors of very low-density lipoprotein together explaining 40.2% of the overall variance. Logistic regression revealed PCOS status to be the only independent determinant of a non-A LDL pattern (odds ratio 5.48 (95% confidence interval 1.082-27.77; P<0.05). CONCLUSIONS: Compared with women matched for BMI and IR, women with PCOS have potentially important differences in lipid profile with greater very low-density lipoprotein levels and increased rates of a more atherogenic non-A LDL pattern.Language
engISSN
1945-7197 (Electronic)0021-972X (Linking)
ae974a485f413a2113503eed53cd6c53
10.1210/jc.2009-2444
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