Non-steroidal anti-inflammatory drug prescriptions in hospital inpatients: are we assessing the risks?
AffiliationDepartment of Rheumatology, Adelaide and Meath Hospital incorporating the, National Children's Hospital, Tallaght, Dublin 24, Ireland. firstname.lastname@example.org
MeSHAnti-Inflammatory Agents, Non-Steroidal/*therapeutic use
Inappropriate Prescribing/*statistics & numerical data
Physician's Practice Patterns/*statistics & numerical data
Proton Pump Inhibitors/therapeutic use
Renal Insufficiency, Chronic/epidemiology
MetadataShow full item record
CitationIr J Med Sci. 2010 Sep;179(3):357-60. Epub 2010 May 30.
JournalIrish journal of medical science
AbstractAIM: To determine non-steroidal anti-inflammatory drug (NSAID) prescribing practices in a tertiary referral hospital. METHODS: A single time-point audit of drug kardexes and clinical notes of n = 388 patients on 2 July 2008 was carried out assessing demographics, gastrointestinal and coronary heart disease risk factors, renal function and co-prescribed medications. RESULTS: Fifty-seven of 388 (14.7%) hospital patients were on NSAIDs. Forty-nine were prescribed NSAID after admission. Nineteen (32.2%) were on regular NSAID (11/19 on PPI) and 38 patients were on PRN NSAID (12/38 on PPI). Seventeen of 49 patients were on other medications associated with gastrointestinal bleeding (10/17 were on PPI). Nineteen patients (33.3%) were >60 years. Eight patients had three or four risk factors for gastrointestinal bleeding; six were on PPI. Thirteen patients had two risks; 7 were on PPI. Six of 19 patients with one risk factor were on PPI. 40.3% had stage 2/3 chronic kidney disease. 35.1% had ischaemic heart disease. CONCLUSIONS: NSAIDs and PPIs are often prescribed inappropriately.
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