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    Non-steroidal anti-inflammatory drug prescriptions in hospital inpatients: are we assessing the risks?

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    Authors
    Kitchen, J
    Kane, D
    Affiliation
    Department of Rheumatology, Adelaide and Meath Hospital incorporating the, National Children's Hospital, Tallaght, Dublin 24, Ireland. kitchen.jo@gmail.com
    Issue Date
    2012-02-01T10:49:13Z
    MeSH
    Anti-Inflammatory Agents, Non-Steroidal/*therapeutic use
    Gastrointestinal Hemorrhage/epidemiology
    Hospitalization
    Humans
    Inappropriate Prescribing/*statistics & numerical data
    Ireland
    Medical Audit
    Physician's Practice Patterns/*statistics & numerical data
    Proton Pump Inhibitors/therapeutic use
    Renal Insufficiency, Chronic/epidemiology
    Risk Factors
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    Citation
    Ir J Med Sci. 2010 Sep;179(3):357-60. Epub 2010 May 30.
    Journal
    Irish journal of medical science
    URI
    http://hdl.handle.net/10147/207889
    DOI
    10.1007/s11845-010-0496-0
    PubMed ID
    20512664
    Abstract
    AIM: To determine non-steroidal anti-inflammatory drug (NSAID) prescribing practices in a tertiary referral hospital. METHODS: A single time-point audit of drug kardexes and clinical notes of n = 388 patients on 2 July 2008 was carried out assessing demographics, gastrointestinal and coronary heart disease risk factors, renal function and co-prescribed medications. RESULTS: Fifty-seven of 388 (14.7%) hospital patients were on NSAIDs. Forty-nine were prescribed NSAID after admission. Nineteen (32.2%) were on regular NSAID (11/19 on PPI) and 38 patients were on PRN NSAID (12/38 on PPI). Seventeen of 49 patients were on other medications associated with gastrointestinal bleeding (10/17 were on PPI). Nineteen patients (33.3%) were >60 years. Eight patients had three or four risk factors for gastrointestinal bleeding; six were on PPI. Thirteen patients had two risks; 7 were on PPI. Six of 19 patients with one risk factor were on PPI. 40.3% had stage 2/3 chronic kidney disease. 35.1% had ischaemic heart disease. CONCLUSIONS: NSAIDs and PPIs are often prescribed inappropriately.
    Language
    eng
    ISSN
    1863-4362 (Electronic)
    0021-1265 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1007/s11845-010-0496-0
    Scopus Count
    Collections
    Tallaght University Hospital

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