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    Enhanced ex vivo inhibition of platelet function following addition of dipyridamole to aspirin after transient ischaemic attack or ischaemic stroke: first results from the TRinity AntiPlatelet responsiveness (TrAP) study.

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    Authors
    Tobin, William Oliver
    Kinsella, Justin A
    Collins, Daniel Ronan
    Coughlan, Tara
    O'Neill, Desmond
    Egan, Bridget
    Tierney, Sean
    Feeley, Thomas Martin
    Murphy, Raymond P
    McCabe, Dominick J H
    Affiliation
    Department of Neurology, The Adelaide and Meath Hospital/National Children's, Hospital, Tallaght, Dublin, UK.
    Issue Date
    2012-02-01T10:49:11Z
    MeSH
    Adult
    Aged
    Aspirin/*pharmacology/therapeutic use
    Blood Platelets/*drug effects/physiology
    Blood Specimen Collection/methods
    Dipyridamole/*pharmacology/therapeutic use
    Drug Therapy, Combination
    Female
    Humans
    Ischemic Attack, Transient/*blood/drug therapy
    Longitudinal Studies
    Male
    Middle Aged
    Platelet Activation/drug effects
    Platelet Aggregation Inhibitors/*pharmacology/therapeutic use
    Platelet Function Tests
    Stroke/*blood/drug therapy
    Show allShow less
    
    Metadata
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    Citation
    Br J Haematol. 2011 Mar;152(5):640-7. doi: 10.1111/j.1365-2141.2010.08539.x. Epub, 2011 Jan 12.
    Journal
    British journal of haematology
    URI
    http://hdl.handle.net/10147/207888
    DOI
    10.1111/j.1365-2141.2010.08539.x
    PubMed ID
    21223254
    Abstract
    Ex vivo dipyridamole 'non-responsiveness' has not been extensively studied in ischaemic cerebrovascular disease. Platelet surface marker expression, leucocyte-platelet complex formation and inhibition of platelet function at high shear stress as detected by the PFA-100(R) Collagen-Adenosine-diphosphate (C-ADP) and Collagen-Epinephrine cartridges was assessed in 52 patients within 4 weeks of transient ischaemic attack (TIA) or ischaemic stroke on aspirin, and then 14 d (14 d) and >90 d (90 d) after adding dipyridamole. A novel definition of 'Dipyridamole non-responsiveness' was used. The median C-ADP closure time increased following addition of dipyridamole, remained elevated at 90 d (P /= 0.5), at 14 and 90 d versus baseline. Additional inhibition of platelet function has been detected with the PFA-100 when dipyridamole is added to aspirin. Elevated monocyte-platelet complexes may contribute to ex vivo dipyridamole non-responsiveness.
    Language
    eng
    ISSN
    1365-2141 (Electronic)
    0007-1048 (Linking)
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2141.2010.08539.x
    Scopus Count
    Collections
    Tallaght University Hospital

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