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    Neuropsychiatric complications associated with interferon - alpha -2b treatment of malignant melanoma.

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    Authors
    Enudi, W
    Udolu, O J
    Affiliation
    Adelaide and Meath Hospital, Tallaght, Ireland. waltenudi@yahoo.com
    Issue Date
    2012-02-01T10:49:08Z
    MeSH
    Adult
    Antimanic Agents/therapeutic use
    Antineoplastic Agents/*adverse effects/therapeutic use
    Antipsychotic Agents/therapeutic use
    Benzodiazepines/therapeutic use
    Bipolar Disorder/*chemically induced/diagnosis/drug therapy/psychology
    Dose-Response Relationship, Drug
    Humans
    Interferon-alpha/*adverse effects/therapeutic use
    Male
    Melanoma/*drug therapy
    Recombinant Proteins
    Skin Neoplasms/*drug therapy
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    Citation
    Afr J Psychiatry (Johannesbg). 2009 Aug;12(3):227-8.
    Journal
    African journal of psychiatry
    URI
    http://hdl.handle.net/10147/207886
    PubMed ID
    19750253
    Abstract
    Several adverse effects have been associated with interferon alpha 2b treatment and neuropsychiatric effects have also been commonly reported. Psychosis and mood disorders have been described in the literature. This case report is of a 30 year old man with malignant melanoma stage 3a who was receiving adjuvant alpha 2b interferon and developed a manic episode two weeks post switching after one month of treatment on a high dose to a low dose. There was no previous psychiatric illness and no known family history of mental illness. This is in keeping with previous reports that mania has been observed in patients undergoing interferon treatment especially after significant dose-reduction or treatment breaks. Mania induced by interferon responds well to antimanic drugs .Since interferon alpha 2b is now commonly used in the treatment of malignant melanoma and other conditions, the need to be aware of its neuropsychiatric complications is essential.
    Language
    eng
    ISSN
    1994-8220 (Print)
    Collections
    Tallaght University Hospital

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